Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | GSTO1 | P78417 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11354624 | 0.88 | CA1 (0.48) | L3MBTL1GSTO1SMN1; SMN2POLBF10 | |
| SCHEMBL11348810 | 0.86 | GSTO1 (0.44) | L3MBTL1GSTO1CYP2C19CYP1A2TSHR | |
| SCHEMBL11340154 | 0.85 | GSTO1 (0.49) | L3MBTL1GSTO1CYP2C19CYP1A2TSHR | |
| SCHEMBL11595726 | 0.83 | F10 (0.46) | L3MBTL1GSTO1CYP2C19CYP1A2TSHR | |
| SCHEMBL11344938 | 0.81 | CA1 (0.54) | CA12CA9 | |
| SCHEMBL11597366 | 0.81 | GSTO1 (0.50) | L3MBTL1GSTO1CYP2C19CYP1A2TSHR | |
| SCHEMBL9436722 | 0.81 | POLB (0.58) | L3MBTL1SMN1; SMN2POLBF10PRSS1 | |
| SCHEMBL11345142 | 0.79 | FABP4 (0.49) | CYP2C19CYP1A2TSHRSMN1; SMN2TDP1 | |
| SCHEMBL5506453 | 0.79 | FABP4 (0.49) | CYP2C19CYP1A2TSHRSMN1; SMN2TDP1 | |
| SCHEMBL11339928 | 0.79 | SMN1; SMN2 (0.53) | L3MBTL1GSTO1CYP2C19CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0001051-B1 | DERIVATIVES OF BENZENESULFONAMIDE, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-02-11 | — | — | EP | disclosed |
| US-4235918-A | SALIDIURETICS, TREATMENT OF HYPERTONIC CONDITIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-11-25 | — | — | US | disclosed |
| EP-0001051-A2 | Derivatives of benzenesulfonamide, method for their preparation and pharmaceutical compositions containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-03-21 | — | — | EP | disclosed |