Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11595503 | 0.92 | POLB (0.56) | POLBL3MBTL1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL11597366 | 0.89 | GSTO1 (0.50) | POLBL3MBTL1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL3524965 | 0.89 | CA12 (0.54) | POLBL3MBTL1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL11354624 | 0.85 | CA1 (0.48) | POLBL3MBTL1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL11710034 | 0.85 | MAPT (0.56) | POLBL3MBTL1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL13543489 | 0.85 | MAPT (0.73) | POLBL3MBTL1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL11595726 | 0.85 | F10 (0.46) | POLBL3MBTL1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL13543502 | 0.83 | HTT (0.59) | POLBL3MBTL1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL9436712 | 0.83 | GSTO1 (0.66) | POLBL3MBTL1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL11596502 | 0.82 | AKR1C3 (0.62) | POLBL3MBTL1TDP1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292755-A | USPA benzolyguanidines | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-03-08 | — | — | US | disclosed |
| US-5091394-A | BENZOYLGUANIDINES, A PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-25 | — | — | US | disclosed |