Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 7/20 | 0.38 |
| ▸ | PPARD | Q03181 | 7/20 | 0.38 |
| ▸ | PPARA | Q07869 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10975462 | 0.78 | PDE5A (0.51) | PDE5APPARGPPARDPPARAKDM4E | |
| SCHEMBL9118750 | 0.76 | MAOB (0.47) | PDE5APPARGPPARDPPARAMAOA | |
| SCHEMBL9121837 | 0.70 | LMNA (0.48) | PDE5AKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL7041646 | 0.69 | PPARA (0.53) | PPARGPPARDPPARA | |
| SCHEMBL6561528 | 0.67 | KDM4E (0.49) | PDE5AKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL10972035 | 0.67 | PDE5A (0.52) | PDE5APPARGPPARDPPARAKDM4E | |
| SCHEMBL6559983 | 0.67 | MAOB (0.43) | PDE5AKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL7038827 | 0.66 | PPARA (0.46) | PPARGPPARDPPARA | |
| SCHEMBL11443590 | 0.66 | MAPK14 (0.39) | PDE5AKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL6559981 | 0.66 | PDE5A (0.48) | PDE5AKDM4EALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4281008-A | Pharmaceutical heterocyclic compounds and compositions | FISONS LIMITED (GB) | 1981-07-28 | — | — | US | disclosed |