Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.46 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11369993 | 0.85 | MEN1 (0.50) | MEN1KMT2ANPSR1KDM1ASMN1; SMN2 | |
| SCHEMBL4458368 | 0.81 | CCR5 (0.49) | MEN1KMT2ANPSR1KDM1ASMN1; SMN2 | |
| SCHEMBL1488930 | 0.76 | HTR2C (0.48) | MEN1KMT2ANPSR1SMN1; SMN2NPC1 | |
| SCHEMBL4134071 | 0.76 | MEN1 (0.55) | MEN1KMT2ANPSR1KDM1ASMN1; SMN2 | |
| SCHEMBL11368285 | 0.76 | LMNA (0.57) | MEN1KMT2ANPSR1KDM1ASMN1; SMN2 | |
| SCHEMBL11361449 | 0.73 | MEN1 (0.52) | MEN1KMT2ANPSR1KDM1ASMN1; SMN2 | |
| SCHEMBL23859760 | 0.73 | SMN1; SMN2 (0.56) | MEN1KMT2ANPSR1KDM1ASMN1; SMN2 | |
| SCHEMBL18075928 | 0.73 | SMN1; SMN2 (0.51) | MEN1KMT2ANPSR1KDM1ASMN1; SMN2 | |
| SCHEMBL934263 | 0.73 | MEN1 (0.64) | MEN1KMT2ANPSR1KDM1ASMN1; SMN2 | |
| SCHEMBL2425665 | 0.73 | MEN1 (0.54) | MEN1KMT2ANPSR1KDM1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4255432-A | ANTIHYPERTENSIVE AGENTS, ANTIHISTAMINES, BRONCHODILATOR AGENTS, ANTIVASOSPASTIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1981-03-10 | — | — | US | disclosed |
| US-4244961-A | 1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents | SYNTEX (U.S.A.) INC. (US) | 1981-01-13 | — | — | US | disclosed |