Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.41 |
| ▸ | HTR3B | O95264 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10864417 | 0.84 | GALR3 (0.43) | NPC1ALDH1A1HPGDHTR3AMAPT | |
| SCHEMBL10832383 | 0.81 | POLB (0.42) | NPC1ALDH1A1HPGDGSK3BMAPT | |
| Clonidine SCHEMBL1369983 | 0.77 | MAPT (0.36) | NPC1GSK3BMAPTLMNAMEN1 | |
| Clonidine SCHEMBL5982 | 0.77 | MAPT (0.36) | NPC1GSK3BMAPTLMNAMEN1 | |
| SCHEMBL5157568 | 0.76 | HPGD (0.47) | ALDH1A1HPGDMAPTSMN1; SMN2TSHR | |
| SCHEMBL5157866 | 0.76 | ITGB3 (0.40) | HPGDMAPTLMNAMEN1KMT2A | |
| Clonidine SCHEMBL10972183 | 0.75 | ADRA2A (0.36) | GSK3BMAPTLMNAMEN1KMT2A | |
| Clonidine SCHEMBL40751 | 0.75 | ADRA2A (0.36) | GSK3BMAPTLMNAMEN1KMT2A | |
| Clonidine SCHEMBL22127030 | 0.75 | MAPT (0.35) | GSK3BMAPTLMNAMEN1KMT2A | |
| Clonidine SCHEMBL9838987 | 0.75 | MAPT (0.35) | GSK3BMAPTLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0035393-A1 | Poultry feeds containing and methods of using anovulatory compounds, and novel anovulatory imidazolines | MERCK & CO. INC. (US) | 1981-09-09 | — | — | EP | disclosed |
| US-4287201-A | CONTAINING A 2-(SUBSTITUTED PHENYLIMINO)IMIDAZOLIDINE COMPOUND | MERCK & CO., INC. (US) | 1981-09-01 | — | — | US | disclosed |