Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | MAOB | P27338 | 1/20 | 0.67 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.63 |
| ▸ | FBP1 | P09467 | 2/20 | 0.61 |
| ▸ | VCP | P55072 | 1/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.60 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.58 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.58 |
| ▸ | ITGAL | P20701 | 1/20 | 0.58 |
| ▸ | TGM2 | P21980 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29626671 | 1.00 | MAPT (0.67) | MAPTMAOBNFE2L2FBP1VCP | |
| SCHEMBL1136435 | 1.00 | MAPT (0.67) | MAPTMAOBNFE2L2FBP1VCP | |
| SCHEMBL29750518 | 1.00 | MAPT (0.67) | MAPTMAOBNFE2L2FBP1VCP | |
| SCHEMBL2744313 | 0.87 | MAPT (0.70) | MAPTMAOBNFE2L2FBP1VCP | |
| SCHEMBL2744320 | 0.87 | MAPT (0.70) | MAPTMAOBNFE2L2FBP1VCP | |
| 3-Nitro-Cinnamic Acid SCHEMBL426380 | 0.85 | MAPT (0.73) | MAPTMAOBNFE2L2FBP1VCP | |
| 3-Nitro-Cinnamic Acid SCHEMBL3290556 | 0.85 | MAPT (0.73) | MAPTMAOBNFE2L2FBP1VCP | |
| 3-Nitro-Cinnamic Acid SCHEMBL4179178 | 0.85 | MAPT (0.73) | MAPTMAOBNFE2L2FBP1VCP | |
| 3-Nitro-Cinnamic Acid SCHEMBL29626695 | 0.85 | MAPT (0.73) | MAPTMAOBNFE2L2FBP1VCP | |
| 3-Nitro-Cinnamic Acid SCHEMBL448381 | 0.85 | MAPT (0.73) | MAPTMAOBNFE2L2FBP1VCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114478256-B | Preparation method of novel curcumin derivative and application of novel curcumin derivative in liver cancer resistance | 安徽理工大学环境友好材料与职业健康研究院(芜湖) | 2024-02-23 | — | — | CN | claimed |
| CN-117903096-A | Cinnamoyl-substituted unsaturated nitrogen-containing heterocycle-containing oxygen-containing compound, composition, preparation method and application | 贵州大学 | 2024-04-19 | — | — | CN | disclosed |
| CN-108383836-B | Heterocyclic compounds as MEK inhibitors | 鲁宾有限公司 | 2021-11-12 | — | — | CN | disclosed |
| EP-2834237-B1 | HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS | LUPIN LTD (IN) | 2018-06-06 | — | — | EP | disclosed |
| US-9969731-B2 | Heterocyclyl compounds as MEK inhibitors | LUPIN LIMITED (IN) | 2018-05-15 | — | — | US | disclosed |
| US-20170101408-A1 | HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS | LUPIN LIMITED (IN) | 2017-04-13 | — | — | US | disclosed |
| US-9555035-B2 | Heterocyclyl compounds as MEK inhibitors | LUPIN LIMITED (IN) | 2017-01-31 | — | — | US | disclosed |
| US-20160331753-A1 | HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS | LUPIN LIMITED (IN) | 2016-11-17 | — | — | US | disclosed |
| US-9428499-B2 | Heterocyclyl compounds as MEK inhibitors | LUPIN LIMITED (IN) | 2016-08-30 | — | — | US | disclosed |
| US-20150133424-A1 | HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS | LUPIN LIMITED (IN) | 2015-05-14 | — | — | US | disclosed |
| US-4410696-A | Antitumor and immunosuppressive 4-carbamoylimidazolium-5-olate derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-10-18 | — | — | US | disclosed |
| EP-0050977-B1 | CARBOXAMIDE COMPOUNDS AS SRS-A ANTAGONISTS AND A PROCESS FOR PRODUCING SAME | PFIZER INC. (US) | 1983-09-14 | — | — | EP | disclosed |
| EP-0075629-A1 | Imidazole derivatives, their preparation, and their pharmaceutical compositions | Sumitomo Chemical Industries Ltd. (JP) | 1983-04-06 | — | — | EP | disclosed |
| US-4343813-A | ANTIANAPHYLACTIC AGENTS | PFIZER INC. (US) | 1982-08-10 | — | — | US | disclosed |
| US-4331683-A | SENSITIZATION, ANTIALLERGENS | PFIZER INC. (US) | 1982-05-25 | — | — | US | disclosed |
| EP-0050977-A1 | Carboxamide compounds as SRS-A antagonists and a process for producing same | PFIZER INC. (US) | 1982-05-05 | — | — | EP | disclosed |
| EP-0047119-A1 | Carboxamide compounds as SRS-A antagonists, pharmaceutical compositions containing them, processes for the preparation, and intermediates useful therein | PFIZER INC. (US) | 1982-03-10 | — | — | EP | disclosed |
| US-4296129-A | ANTIAASTHMATIC INHIBITOR OF SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS | PFIZER, INC. (US) | 1981-10-20 | — | — | US | disclosed |
| US-4296120-A | ANTIANAPHYLACTIC | PFIZER INC. (US) | 1981-10-20 | — | — | US | disclosed |
| US-4264713-A | COMPRISING LIGHT SENSITIVE POLYMERS OF AN UNSATURATED POLYESTER AND AN ACRYLIC POLYMER WITH UNSATURATED SIDE CHAINS | FUJI PHOTO FILM CO., LTD. (JP) | 1981-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160331753-A1 | HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS | NRAS, BRAF, KRAS | MAPT 3995/4885MAOB 711/4885NFE2L2 941/4885 |
| US-20150133424-A1 | HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS | NRAS, BRAF, KRAS | MAPT 3995/4885MAOB 711/4885NFE2L2 941/4885 |
| US-20170101408-A1 | HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS | NRAS, BRAF, KRAS | MAPT 3995/4885MAOB 711/4885NFE2L2 941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.