3-Nitro-Cinnamic Acid

3-Nitro-Cinnamic Acid

SCHEMBL3290556

O=C(O)C=Cc1cccc([N+](=O)[O-])c1

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.73
MAOB P27338 1/20 0.73
NFE2L2 Q16236 1/20 0.70
FBP1 P09467 1/20 0.63
VCP P55072 1/20 0.63
CYP19A1 P11511 1/20 0.63
ALDH1A1 P00352 3/20 0.63
MEN1 O00255 2/20 0.63
KMT2A Q03164 2/20 0.63
HSP90AA1 P07900 3/20 0.62
MITF O75030 1/20 0.62
LMNA P02545 1/20 0.62
HTT P42858 1/20 0.62
ATM Q13315 1/20 0.62
SMN1; SMN2 Q16637 1/20 0.61
TRPM8 Q7Z2W7 1/20 0.60
ITGB2 P05107 1/20 0.59
ICAM1 P05362 1/20 0.59
ITGAL P20701 1/20 0.59
TGM2 P21980 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
3-Nitro-Cinnamic Acid SCHEMBL426380 1.00 MAPT (0.73) MAPTMAOBNFE2L2FBP1VCP
3-Nitro-Cinnamic Acid SCHEMBL448381 1.00 MAPT (0.73) MAPTMAOBNFE2L2FBP1VCP
3-Nitro-Cinnamic Acid SCHEMBL29626695 1.00 MAPT (0.73) MAPTMAOBNFE2L2FBP1VCP
3-Nitro-Cinnamic Acid SCHEMBL4179178 1.00 MAPT (0.73) MAPTMAOBNFE2L2FBP1VCP
3-Nitro-Cinnamic Acid SCHEMBL7990710 0.98 MAPT (0.71) MAPTMAOBNFE2L2FBP1VCP
3-Nitro-Cinnamic Acid SCHEMBL27877632 0.98 MAPT (0.71) MAPTMAOBNFE2L2FBP1VCP
3-Nitro-Cinnamic Acid SCHEMBL7401665 0.98 MAPT (0.71) MAPTMAOBNFE2L2FBP1VCP
3-Nitro-Cinnamic Acid SCHEMBL7990708 0.97 MAPT (0.69) MAPTMAOBNFE2L2FBP1VCP
SCHEMBL5209312 0.91 MAPT (0.62) MAPTMAOBNFE2L2FBP1VCP
SCHEMBL5209309 0.91 MAPT (0.62) MAPTMAOBNFE2L2FBP1VCP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190256459-A1 NOVEL PROCESS FOR THE PREPARATION OF BELINOSTAT BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) 2019-08-22 US claimed
WO-2017199264-A1 NOVEL PROCESS FOR THE PREPARATION OF BELINOSTAT BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) 2017-11-23 WO claimed
US-7732625-B2 Colorant compounds XEROX CORPORATION (US) 2010-06-08 US claimed
US-7311767-B2 Forming a salt of a liquid phase change ink carrier of stearyl stearamide, an amine substituted Xanthene, acridine, anthracene or thioxanthene chromogen, and a metal salt capable of forming a compound with two chromogens XEROX CORPORATION (US) 2007-12-25 US claimed
US-7033424-B2 Phase change inks XEROX CORPORATION (US) 2006-04-25 US claimed
US-20060021546-A1 Processes for preparing phase change inks XEROX CORPORATION 2006-02-02 US claimed
US-20060020141-A1 Metallized dye XEROX CORPORATION 2006-01-26 US claimed
US-20060016369-A1 PHASE CHANGE INKS XEROX CORPORATION 2006-01-26 US claimed
EP-3350165-B1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF ORGANOVO INC (US) 2023-07-26 EP disclosed
US-11214538-B2 Farnesoid X receptor agonists and uses thereof METACRINE, INC. (US) 2022-01-04 US disclosed
US-20210032195-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF ELI LILLY AND COMPANY 2021-02-04 US disclosed
US-10703712-B2 Farnesoid X receptor agonists and uses thereof METACRINE, INC. (US) 2020-07-07 US disclosed
US-10626081-B2 Farnesoid X receptor agonists and uses thereof METACRINE, INC. (US) 2020-04-21 US disclosed
US-20190256459-A1 NOVEL PROCESS FOR THE PREPARATION OF BELINOSTAT BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) 2019-08-22 US disclosed
WO-1997040051-A1 FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-10-30 WO disclosed
EP-0770079-A1 HETEROBICYCLIC DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-05-02 EP disclosed
US-5610144-A CHOLECYSTOKININ OR GASTRIN ANTAGONISTS; NERVOUS SYSTEM AND GASTROINTESTINAL DISORDERS RHONE-POULENC RORER S.A. (FR) 1997-03-11 US disclosed
US-5539074-A LIQUID CRYSTAL POLYMERS ON SILICA FOR LIGHT SENSITIVE ELEMENTS HOFFMANN-LA ROCHE INC. (US) 1996-07-23 US disclosed
WO-1996001825-A1 HETEROBICYCLIC DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-01-25 WO disclosed
US-5382590-A Gastrointestinal disorders and nervous system disorders RHONE-POULENC RORER S.A. (FR) 1995-01-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210032195-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF NR1H4, NR1H2, NR1H3 MAPT 4394/4885MAOB 3732/4885NFE2L2 2167/4885
US-11214538-B2 Farnesoid X receptor agonists and uses thereof NR1H4, NR1H2, NR1H3 MAPT 4394/4885MAOB 3732/4885NFE2L2 2167/4885
US-20060020141-A1 Metallized dye CDYL, CDY1; CDY1B, CDYL2 MAPT 4074/4885MAOB 62/4885NFE2L2 1266/4885
US-20190256459-A1 NOVEL PROCESS FOR THE PREPARATION OF BELINOSTAT ACR, AADAC, CDK11A MAPT 3904/4885MAOB 3164/4885NFE2L2 4402/4885
US-10703712-B2 Farnesoid X receptor agonists and uses thereof NR1H4, NR1H2, NR1H3 MAPT 4394/4885MAOB 3732/4885NFE2L2 2167/4885
US-10626081-B2 Farnesoid X receptor agonists and uses thereof NR1H4, NR1H2, NR1H3 MAPT 4394/4885MAOB 3732/4885NFE2L2 2167/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.