SCHEMBL11364889

SCHEMBL11364889

CNC(=S)Nc1nc2c(s1)C(C)CC(C)(C)C2

nearest known ligand 0.36

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 11/20 0.36
NPC1 O15118 5/20 0.34
RAB9A P51151 5/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
MAPK1 P28482 1/20 0.34
HSD17B10 Q99714 1/20 0.34
KDM4E B2RXH2 3/20 0.33
HPGD P15428 2/20 0.33
HTT P42858 2/20 0.33
SMN1; SMN2 Q16637 4/20 0.32
TP53 P04637 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11356665 0.84 ALDH1A1 (0.41) ALDH1A1NPC1RAB9AL3MBTL1MAPK1
SCHEMBL11364883 0.76 ALDH1A1 (0.39) ALDH1A1NPC1RAB9AL3MBTL1MAPK1
SCHEMBL11227526 0.69 ALDH1A1 (0.47) ALDH1A1
SCHEMBL11235834 0.59 NPC1 (0.30) ALDH1A1NPC1RAB9A
SCHEMBL10367922 0.57 ALDH1A1 (0.70) ALDH1A1NPC1RAB9AL3MBTL1MAPK1
SCHEMBL11361298 0.57 ALDH1A1 (0.40) ALDH1A1NPC1RAB9AL3MBTL1MAPK1
SCHEMBL691885 0.53 ALDH1A1 (0.73) ALDH1A1NPC1RAB9AL3MBTL1MAPK1
SCHEMBL27283642 0.51 RAB9A (0.60) ALDH1A1NPC1RAB9AL3MBTL1MAPK1
SCHEMBL11697603 0.50
SCHEMBL8550068 0.48 ALDH1A1 (0.37) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4289524-A Herbicidal 3-(tetrahydrobenzothiazol-2-yl)tetrahydro-1,3,5-oxadiazin-4-ones VELSICOL CHEMICAL COPORATION (US) 1981-09-15 US disclosed