Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11359942 | 0.91 | RXFP1 (0.67) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL10872303 | 0.86 | ADORA2B (0.55) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL10967382 | 0.79 | MAPK1 (0.82) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL5237698 | 0.77 | ADORA2B (0.72) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL11356563 | 0.76 | TRPA1 (0.46) | RXFP1MAPK1LMNAADORA2BSMN1; SMN2 | |
| SCHEMBL11357494 | 0.76 | TRPA1 (0.44) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL5272670 | 0.75 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL7612452 | 0.74 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL5275531 | 0.74 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL9842692 | 0.72 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4291037-A | PROMOTING THE FLOW OF BLOOD THROUGH SKELETAL MUSCLES VASODILATORS | Wulfing, Johann A. (DE) | 1981-09-22 | — | — | US | claimed |