Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CA2 | P00918 | 4/20 | 0.46 |
| ▸ | CA7 | P43166 | 3/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL146841 | 0.80 | CA1 (0.61) | CA1CA2CA7CA9CA12 | |
| Guaiacol SCHEMBL3288239 | 0.78 | CA1 (0.60) | CA1CA2CA7CA9CA12 | |
| Boric Acid SCHEMBL5237071 | 0.76 | ENPP2 (0.54) | CA1CA2CA7CA9CA12 | |
| Syringol SCHEMBL6049239 | 0.75 | CA1 (0.55) | CA1CA2CA7CA9CA12 | |
| SCHEMBL78554 | 0.73 | CA1 (0.52) | CA1CA2CA7CA9CA12 | |
| SCHEMBL7921177 | 0.73 | CA1 (0.52) | CA1CA2CA7CA9CA12 | |
| SCHEMBL29352478 | 0.73 | CA1 (0.52) | CA1CA2CA7CA9CA12 | |
| Guaiacol SCHEMBL678968 | 0.73 | CA1 (0.60) | CA1CA2CA7CA9CA12 | |
| SCHEMBL28575044 | 0.73 | CA1 (0.52) | CA1CA2CA7CA9CA12 | |
| Guaiacol SCHEMBL9363005 | 0.73 | CA1 (0.60) | CA1CA2CA7CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651690-B1 | PROCESS FOR THE PREPARATION OF A POLYOLEFIN | LANXESS ELASTOMERS BV (NL) | 2015-07-01 | — | — | EP | disclosed |
| EP-1651686-B1 | IMPROVED METHOD OF PREPARING A HYDROCARBYLATED METAL-ORGANIC COMPOUND | LANXESS ELASTOMERS BV (NL) | 2013-10-16 | — | — | EP | disclosed |
| EP-1730205-B1 | POLIMERIZATION CATALYST COMPRISING AN AMIDINE LIGAND | LANXESS ELASTOMERS BV (NL) | 2012-09-26 | — | — | EP | disclosed |
| US-7956140-B2 | Polymerization catalyst comprising amidine ligand | DSM IP ASSETS B.V. (NL) | 2011-06-07 | — | — | US | disclosed |
| EP-1781716-B1 | PROCESS FOR THE PREPARATION OF A POLYMER | DSM IP ASSETS BV (NL) | 2011-02-23 | — | — | EP | disclosed |
| US-7816548-B2 | Method of preparing a hydrocarbylated metal-organic compound | DSM IP ASSETS B.V. (NL) | 2010-10-19 | — | — | US | disclosed |
| US-7547751-B2 | Process for the preparation of a polyolefin | DSM IP ASSETS B.V. (NL) | 2009-06-16 | — | — | US | disclosed |
| US-20090043060-A1 | Process For the Preparation of a Polymer | DSM IP ASSETS B.V. (NL) | 2009-02-12 | — | — | US | disclosed |
| US-20090012246-A1 | Polymerization Catalyst Comprising Amidine Ligand | DMS IP ASSETS B.V. (NL) | 2009-01-08 | — | — | US | disclosed |
| US-20080153999-A1 | Polymerization of at least one aliphatic or aromatic hydrocarbyl C2-20 mono- or multiolefin in the presence of a catalyst and a boron comprising co-catalyst, wherein the catalyst comprises of a metal-organic reagent, a spectator ligand and optionally at least one equivalent of a hydrocarbylting agent | ARLANXEO NETHERLANDS B.V. (NL) | 2008-06-26 | — | — | US | disclosed |
| US-20060252893-A1 | Process for the preparation of a polyolefin | ARLANXEO NETHERLANDS B.V. (NL) | 2006-11-09 | — | — | US | disclosed |
| EP-1651690-A2 | PROCESS FOR THE PREPARATION OF A POLYOLEFIN | DSM IP Assets B.V. (NL) | 2006-05-03 | — | — | EP | disclosed |
| EP-1651691-A2 | PROCESS FOR THE PREPARATION OF A POLYOLEFIN | DSM IP Assets B.V. (NL) | 2006-05-03 | — | — | EP | disclosed |
| EP-1651686-A1 | IMPROVED METHOD OF PREPARING A HYDROCARBYLATED METAL-ORGANIC COMPOUND | DSM IP Assets B.V. (NL) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005123790-A1 | PROCESS FOR THE PREPARATION OF A POLYMER | DSM IP ASSETS B.V. (NL) | 2005-12-29 | — | — | WO | disclosed |
| WO-2005090418-A1 | POLIMERIZATION CATALYST COMPRISING AN AMIDINE LIGAND | DSM IP ASSETS B.V. (NL) | 2005-09-29 | — | — | WO | disclosed |
| EP-1535936-A1 | Improved method of preparing a hydrocarbylated metal-organic compound | DSM IP Assets B.V. (NL) | 2005-06-01 | — | — | EP | disclosed |
| WO-2005014601-A2 | PROCESS FOR THE PREPARATION OF A POLYOLEFIN | DSM IP ASSETS B.V. (NL) | 2005-02-17 | — | — | WO | disclosed |
| WO-2005014669-A1 | IMPROVED METHOD OF PREPARING A HYDROCARBYLATED METAL-ORGANIC COMPOUND | DSM IP ASSETS B.V. (NL) | 2005-02-17 | — | — | WO | disclosed |
| WO-2005014674-A2 | PROCESS FOR THE PREPARATION OF A POLYOLEFIN | DSM IP ASSETS B.V. (NL) | 2005-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012246-A1 | Polymerization Catalyst Comprising Amidine Ligand | AP2M1, SNW1, BZW1 | CA1 3187/4885CA2 3922/4885CA7 3296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.