SCHEMBL11368784

SCHEMBL11368784

CCOC(=O)C1=C(C)NC(C)=C([N+](=O)[O-])C1c1cccc(OC(F)(F)F)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 13/20 0.62
CACNA1F O60840 11/20 0.62
CACNA1D Q01668 11/20 0.62
CACNA1S Q13698 11/20 0.62
ADORA3 P0DMS8 4/20 0.62
CYP1A2 P05177 5/20 0.58
CYP3A4 P08684 5/20 0.58
CYP2C9 P11712 5/20 0.58
CYP2C19 P33261 5/20 0.58
MAPT P10636 5/20 0.58
HIF1A Q16665 3/20 0.58
MEN1 O00255 3/20 0.58
KMT2A Q03164 3/20 0.58
TSHR P16473 3/20 0.58
NFKB1 P19838 3/20 0.58
CYP2D6 P10635 2/20 0.58
LMNA P02545 1/20 0.58
POLB P06746 1/20 0.58
MAPK1 P28482 1/20 0.58
GPR55 Q9Y2T6 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7265309 0.89 CACNA1C (0.51) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL7272283 0.84 ADORA3 (0.57) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL11380790 0.84 CACNA1F (0.87) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL11363662 0.83 CACNA1F (0.67) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL8680780 0.83 ADORA3 (0.67) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL11010524 0.82 CYP1A2 (0.63) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL11363036 0.79 CACNA1C (0.74) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL7265346 0.78 CYP1A2 (0.80) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL11362916 0.78 ADORA3 (0.65) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL11013178 0.78 CACNA1F (0.59) CACNA1CCACNA1FCACNA1DCACNA1SADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4248873-A Nitro-substituted 1,4-dihydropyridines, processes for _their production and their medicinal use BAYER AKTIENGESELLSCHAFT (DE) 1981-02-03 US disclosed