SCHEMBL8680780

SCHEMBL8680780

CCOC(=O)C1=C(C)NC(C)=C([N+](=O)[O-])C1c1ccccc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 3/20 0.67
CACNA1C Q13936 10/20 0.65
CACNA1F O60840 9/20 0.65
CACNA1D Q01668 9/20 0.65
CACNA1S Q13698 9/20 0.65
HIF1A Q16665 3/20 0.60
MAPT P10636 3/20 0.60
MEN1 O00255 2/20 0.60
CYP1A2 P05177 2/20 0.60
CYP3A4 P08684 2/20 0.60
CYP2C9 P11712 2/20 0.60
CYP2C19 P33261 2/20 0.60
KMT2A Q03164 2/20 0.60
TSHR P16473 2/20 0.60
LMNA P02545 1/20 0.60
POLB P06746 1/20 0.60
MAPK1 P28482 1/20 0.60
GPR55 Q9Y2T6 1/20 0.60
CYP2D6 P10635 1/20 0.60
NFKB1 P19838 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11362916 0.90 ADORA3 (0.65) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL10735610 0.89 CACNA1C (0.55) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL10731028 0.88 CACNA1C (0.57) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL11380790 0.87 CACNA1F (0.87) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL11013178 0.87 CACNA1F (0.59) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL2849115 0.87 MAPT (0.66) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL2849117 0.87 MAPT (0.66) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL11372026 0.87 LMNA (0.75) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL11363662 0.86 CACNA1F (0.67) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL11007622 0.85 CACNA1C (0.58) ADORA3CACNA1CCACNA1FCACNA1DCACNA1S

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-10067743-A None JP disclosed
JP-H1067743-A CARBOXYLIC ACID DERIVATIVE BAYER AG 1998-03-10 JP disclosed