Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11374984 | 0.90 | ESR2 (0.47) | CNR1CNR2ESR1ESR2GABRA1 | |
| SCHEMBL11306858 | 0.86 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4DGABRA1 | |
| SCHEMBL11372160 | 0.85 | HCAR1 (0.43) | PDE4BPDE4DCNR1CNR2ESR1 | |
| SCHEMBL11372681 | 0.85 | POLB (0.48) | PDE4BPDE4APDE4CPDE4DCNR1 | |
| SCHEMBL11372451 | 0.85 | ESR2 (0.52) | PDE4DCNR1CNR2ESR1ESR2 | |
| SCHEMBL10979002 | 0.82 | CNR1 (0.51) | PDE4BPDE4APDE4CPDE4DCNR1 | |
| SCHEMBL10973972 | 0.79 | CNR1 (0.57) | PDE4BPDE4APDE4CPDE4DCNR1 | |
| SCHEMBL11075597 | 0.79 | CNR1 (0.56) | PDE4BPDE4APDE4CPDE4DCNR1 | |
| SCHEMBL11370933 | 0.79 | CNR1 (0.48) | PDE4BPDE4APDE4CPDE4DCNR1 | |
| SCHEMBL10975710 | 0.79 | CNR1 (0.54) | PDE4BPDE4APDE4CPDE4DCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4276295-A | VASODILATORS, HYPOTENSIVE, ANTIATHEROSCLEROTIC | Ishikawa, Masayuki (JP) | 1981-06-30 | — | — | US | claimed |