SCHEMBL1137074

SCHEMBL1137074

Nc1nccc(Oc2ccc([N+](=O)[O-])cc2F)c1I

nearest known ligand 0.49

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HSPB1 P04792 5/20 0.49
MET P08581 7/20 0.43
KDR P35968 4/20 0.43
S1PR4 O95977 1/20 0.43
ALDH1A1 P00352 3/20 0.40
MAPT P10636 3/20 0.40
MAPK1 P28482 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
GAA P10253 1/20 0.39
HTT P42858 1/20 0.39
PDE7A Q13946 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30495857 1.00 HSPB1 (0.49) HSPB1METKDRS1PR4ALDH1A1
SCHEMBL31007140 0.86 HSPB1 (0.36) HSPB1METKDRS1PR4ALDH1A1
SCHEMBL26012029 0.85 HSPB1 (0.49) HSPB1S1PR4ALDH1A1MAPTMAPK1
SCHEMBL30844466 0.85 MET (0.49) HSPB1METKDRS1PR4MEN1
SCHEMBL15879036 0.85 MET (0.49) HSPB1METKDRS1PR4MEN1
SCHEMBL12386001 0.83 HSPB1 (0.47) HSPB1METKDRS1PR4ALDH1A1
SCHEMBL2591029 0.82 MET (0.39) HSPB1METKDRALDH1A1MAPT
SCHEMBL1137087 0.82 HSPB1 (0.46) HSPB1METS1PR4ALDH1A1MAPT
SCHEMBL25362124 0.81 HSPB1 (0.48) HSPB1METS1PR4ALDH1A1MAPT
SCHEMBL31316496 0.81 HSPB1 (0.48) HSPB1METS1PR4ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260132158-A1 PHENYL OXY AMIDE KINASE INHIBITORS THE TRANSLATIONAL GENOMICS RESEARCH INST (US) 2026-05-14 US disclosed
US-12421207-B2 Pyrimidinedione-based compounds as AXL, c-MET, and Mer inhibitors and methods of use thereof CMG PHARMACEUTICAL CO., LTD. (KR) 2025-09-23 US disclosed
US-20250171426-A1 PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF CMG PHARMACEUTICAL CO., LTD. (KR) 2025-05-29 US disclosed
EP-4479397-A1 PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF CMG Pharmaceutical Co., Ltd. (KR) 2024-12-25 EP disclosed
WO-2024077057-A1 PHENYL OXY AMIDE KINASE INHIBITORS THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) 2024-04-11 WO disclosed
US-20230348423-A1 PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF CMG PHARMACEUTICAL CO., LTD. (KR) 2023-11-02 US disclosed
US-20230348423-A1 PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF CMG PHARMACEUTICAL CO., LTD. (KR) 2023-11-02 US disclosed
WO-2023156863-A1 PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF CMG PHARMACEUTICAL CO., LTD. (KR) 2023-08-24 WO disclosed
WO-2023156864-A1 PYRIDAZINONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF CMG PHARMACEUTICAL CO., LTD. (KR) 2023-08-24 WO disclosed
US-20230257364-A1 PYRIDAZINONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF CMG PHARMACEUTICAL CO., LTD. (KR) 2023-08-17 US disclosed
US-20090054436-A1 MONOCYCLIC HETEROCYCLES AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2009-02-26 US disclosed
US-20090054436-A1 MONOCYCLIC HETEROCYCLES AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2009-02-26 US disclosed
US-7459562-B2 Monocyclic heterocycles as kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2008-12-02 US disclosed
US-7459562-B2 Monocyclic heterocycles as kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2008-12-02 US disclosed
CN-101128199-A Monocyclic heterocycles as kinase inhibitors BRISTOL MYERS SQUIBB CO (US) 2008-02-20 CN disclosed
US-20070078140-A1 MET kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY 2007-04-05 US disclosed
US-20070078140-A1 MET kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY 2007-04-05 US disclosed
EP-1737451-A2 MONOCYCLIC HETEROCYCLES AS KINASE INHIBITORS Bristol-Myers Squibb Company (US) 2007-01-03 EP disclosed
WO-2005117867-A2 MONOCYCLIC HETEROCYCLES AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2005-12-15 WO disclosed
US-20050245530-A1 Monocyclic heterocycles as kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY 2005-11-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230257364-A1 PYRIDAZINONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF MERTK, MET, AXL HSPB1 2502/4885MET 2/4885KDR 55/4885
US-20250171426-A1 PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF MERTK, AXL, RET HSPB1 3189/4885MET 4/4885KDR 28/4885
US-20090054436-A1 MONOCYCLIC HETEROCYCLES AS KINASE INHIBITORS CDK2, MAP3K19, CDK1 HSPB1 2521/4885MET 162/4885KDR 472/4885
US-20050245530-A1 Monocyclic heterocycles as kinase inhibitors CDK2, MAP3K19, CDK1 HSPB1 2521/4885MET 162/4885KDR 472/4885
US-20070078140-A1 MET kinase inhibitors MET, ABL1, ERBB2 HSPB1 1525/4885MET 1/4885KDR 129/4885
US-12421207-B2 Pyrimidinedione-based compounds as AXL, c-MET, and Mer inhibitors and methods of use thereof MERTK, AXL, MET HSPB1 2681/4885MET 3/4885KDR 25/4885
US-20260132158-A1 PHENYL OXY AMIDE KINASE INHIBITORS RAF1, CNKSR1, PHKG1 HSPB1 1135/4885MET 186/4885KDR 205/4885
US-20230348423-A1 PYRIMIDINEDIONE-BASED COMPOUNDS AS AXL, C-MET, AND MER INHIBITORS AND METHODS OF USE THEREOF MERTK, AXL, MET HSPB1 2681/4885MET 3/4885KDR 25/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.