Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11363948 | 0.94 | SLC22A1 (0.44) | MEN1MAPTKMT2AHTTSMN1; SMN2 | |
| SCHEMBL23115291 | 0.83 | SLC22A1 (0.55) | SLC22A1PRCPADRB2KDM1A | |
| SCHEMBL23135179 | 0.83 | SLC22A1 (0.55) | SLC22A1PRCPADRB2KDM1A | |
| SCHEMBL23115288 | 0.83 | SLC22A1 (0.55) | SLC22A1PRCPADRB2KDM1A | |
| Acetic Acid SCHEMBL10657697 | 0.81 | CYP2D6 (0.44) | MEN1MAPTKMT2ASMN1; SMN2ALDH1A1 | |
| Acetic Acid SCHEMBL10657706 | 0.81 | CYP2D6 (0.44) | MEN1MAPTKMT2ASMN1; SMN2ALDH1A1 | |
| Acetic Acid SCHEMBL10657702 | 0.81 | CYP2D6 (0.44) | MEN1MAPTKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6437154 | 0.78 | BCHE (0.43) | MEN1MAPTKMT2AALDH1A1KDM4E | |
| SCHEMBL2064742 | 0.78 | BCHE (0.43) | MEN1MAPTKMT2AALDH1A1KDM4E | |
| SCHEMBL6436095 | 0.78 | BCHE (0.43) | MEN1MAPTKMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4194044-A | 1-(P-PHENOXYBENZYL)-(1,2,)3,4,5,6,7,8 -(HEXA)OCTAHYDROISOQUINOLINES | HOFFMANN-LA ROCHE INC. (US) | 1980-03-18 | — | — | US | claimed |
| US-4270000-A | ANALGESICS; FROM AN N-/2-/1-CYCLOHEXEN-1-YL/ ETHYL/-4-PHENOXYPHENYLACETAMIDE | HOFFMANN-LA ROCHE INC. (US) | 1981-05-26 | — | — | US | disclosed |
| US-4247697-A | ANALGESICS | HOFFMANN-LA ROCHE INC. (US) | 1981-01-27 | — | — | US | disclosed |
| US-4194044-A | 1-(P-PHENOXYBENZYL)-(1,2,)3,4,5,6,7,8 -(HEXA)OCTAHYDROISOQUINOLINES | HOFFMANN-LA ROCHE INC. (US) | 1980-03-18 | — | — | US | disclosed |