Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 1/20 | 0.55 |
| ▸ | PRCP | P42785 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23135179 | 1.00 | SLC22A1 (0.55) | SLC22A1PRCPADRB2GRIN2BPOLB | |
| SCHEMBL23115291 | 1.00 | SLC22A1 (0.55) | SLC22A1PRCPADRB2GRIN2BPOLB | |
| SCHEMBL11363948 | 0.88 | SLC22A1 (0.44) | SLC22A1PRCPADRB2GRIN2B | |
| SCHEMBL19427432 | 0.85 | TBXA2R (0.52) | SLC22A1PRCPADRB2GRIN2BKDM1A | |
| SCHEMBL2065898 | 0.85 | DRD2 (0.55) | SLC22A1PRCPADRB2HTR2AHTR2C | |
| SCHEMBL16591499 | 0.85 | PRCP (0.40) | SLC22A1PRCPADRB2KDM1A | |
| SCHEMBL19427420 | 0.85 | DRD2 (0.55) | SLC22A1PRCPADRB2HTR2AHTR2C | |
| SCHEMBL19427382 | 0.85 | PRCP (0.40) | SLC22A1PRCPADRB2KDM1A | |
| Water SCHEMBL9452384 | 0.84 | DRD2 (0.54) | SLC22A1PRCPADRB2HTR2AHTR2C | |
| Oxalic Acid SCHEMBL11370939 | 0.83 | MEN1 (0.44) | SLC22A1PRCPADRB2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110643650-B | Preparation method of (S) -1-benzyl-1, 2,3,4,5,6,7, 8-octahydroisoquinoline compound | 复旦大学 | 2023-03-07 | — | — | CN | claimed |
| US-11345941-B2 | Method for preparing (S)-1-benzyl-1,2,3,4,5,6,7,8-octahydroisoquinoline compound | FUDAN UNIVERSITY (CN) | 2022-05-31 | — | — | US | claimed |
| US-20210087595-A1 | METHOD FOR PREPARING (S)-1-BENZYL-1,2,3,4,5,6,7,8-OCTAHYDROISOQUINOLINE COMPOUND | FUDAN UNIVERSITY (CN) | 2021-03-25 | — | — | US | claimed |
| CN-110643650-A | Preparation method of (S) -1-benzyl-1, 2,3,4,5,6,7, 8-octahydroisoquinoline compound | 复旦大学 | 2020-01-03 | — | — | CN | claimed |
| CN-106632038-B | A kind of method for splitting of octahydro isoquinolin | Jiming Medical Science and Technology (Suzhou) Co., Ltd. (CN) | 2019-10-29 | — | — | CN | claimed |
| CN-104761496-B | Synthesis method of dextromethorphan intermediate | 华东理工大学 | 2017-05-24 | — | — | CN | claimed |
| CN-106632038-A | Resolution method of octahydro isoquinoline | 暨明医药科技（苏州）有限公司 | 2017-05-10 | — | — | CN | claimed |
| CN-103073494-B | The preparation method that ent-3-methoxyl group is muttered | SUZHOU LIXIN PHARMACY CO., LTD. (CN) | 2015-10-07 | — | — | CN | claimed |
| CN-103073495-B | The preparation method that a kind of ent-3-methoxyl group is muttered | SUZHOU LIXIN PHARMACY CO., LTD. (CN) | 2015-08-05 | — | — | CN | claimed |
| CN-103044327-B | Preparation method of dextromethorphan | Suzhou lixin pharmaceutical co ltd | 2014-12-17 | — | — | CN | claimed |
| CN-103265489-A | Preparation method of ent-(14S)-3-methoxyl-17-morphinan | Suzhou lixin pharmaceutical co ltd | 2013-08-28 | — | — | CN | claimed |
| CN-103073494-A | Preparation method of ent-3-methoxymorphinan | Suzhou lixin pharmaceutical co ltd | 2013-05-01 | — | — | CN | claimed |
| CN-103073495-A | Preparation method for ent-3-methoxy-morphinan | Suzhou lixin pharmaceutical co ltd | 2013-05-01 | — | — | CN | claimed |
| CN-103058929-A | Preparation method of octahydro isoquinoline derivative | Suzhou lixin pharmaceutical co ltd | 2013-04-24 | — | — | CN | claimed |
| CN-103058928-A | Preparation method of dextromethorphan intermediate 1-(4-methoxyl) benzyl-1,2,3,4,5,6,7,8-octahydro isoquinoline | Suzhou lixin pharmaceutical co ltd | 2013-04-24 | — | — | CN | claimed |
| CN-102219737-B | Preparation process for key intermediate 1-(4-methoxyl)benzyl-1,2,3,4,5,6,7,8-octahydro isoquinoline (mixed isomer) of dextromethorphan hydrobromide serving as cough relieving medicine | JIANGSU BAOZONG BAODA PHARMACEUTICAL CO LTD | 2012-12-12 | — | — | CN | claimed |
| CN-102219737-A | Preparation process for key intermediate 1-(4-methoxyl)benzyl-1,2,3,4,5,6,7,8-octahydro isoquinoline (mixed isomer) of dextromethorphan hydrobromide serving as cough relieving medicine | JIANGSU BAOZONG BAODA PHARMACEUTICAL CO LTD | 2011-10-19 | — | — | CN | claimed |
| CN-110643650-B | Preparation method of (S) -1-benzyl-1, 2,3,4,5,6,7, 8-octahydroisoquinoline compound | 复旦大学 | 2023-03-07 | — | — | CN | disclosed |
| CN-103044327-A | Preparation method of dextromethorphan | Suzhou lixin pharmaceutical co ltd | 2013-04-17 | — | — | CN | disclosed |
| CN-102219737-A | Preparation process for key intermediate 1-(4-methoxyl)benzyl-1,2,3,4,5,6,7,8-octahydro isoquinoline (mixed isomer) of dextromethorphan hydrobromide serving as cough relieving medicine | JIANGSU BAOZONG BAODA PHARMACEUTICAL CO LTD | 2011-10-19 | — | — | CN | disclosed |