Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 1/20 | 0.61 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | DAO | P14920 | 1/20 | 0.56 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.54 |
| ▸ | CES2 | O00748 | 1/20 | 0.54 |
| ▸ | CES1 | P23141 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL11371951 | 1.00 | APOBEC3A (0.61) | APOBEC3AAPOBEC3GTSHRDAONAPRT | |
| SCHEMBL701728 | 0.91 | TSHR (0.60) | APOBEC3AAPOBEC3GTSHRDAONAPRT | |
| Terephthalic Acid SCHEMBL11371948 | 0.90 | CA2 (0.52) | APOBEC3AAPOBEC3GTSHRDAONAPRT | |
| SCHEMBL9132253 | 0.89 | APOBEC3A (0.48) | APOBEC3AAPOBEC3GTSHRDAONAPRT | |
| SCHEMBL9460527 | 0.89 | HPGD (0.55) | APOBEC3AAPOBEC3GTSHRDAONAPRT | |
| SCHEMBL9136915 | 0.89 | APOBEC3A (0.48) | APOBEC3AAPOBEC3GTSHRDAONAPRT | |
| SCHEMBL9460232 | 0.89 | HPGD (0.55) | APOBEC3AAPOBEC3GTSHRDAONAPRT | |
| Iodide SCHEMBL21857931 | 0.88 | TSHR (0.57) | APOBEC3AAPOBEC3GTSHRDAONAPRT | |
| SCHEMBL9134441 | 0.87 | L3MBTL1 (0.47) | APOBEC3AAPOBEC3GTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL9134477 | 0.87 | L3MBTL1 (0.47) | APOBEC3AAPOBEC3GTSHRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4255553-A | COMPRISING A COMPOUND HAVING AT LEAST TWO EPOXY GROUPS, A POLYESTER OR ACRYLIC RESIN, AND A QUARTERNARY AMMONIUM CARBOXYLATE AS CATALYST | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 1981-03-10 | — | — | US | disclosed |