Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11423013 | 0.95 | HRH3 (0.41) | HRH3LTA4HCYP4F2CYP4A11 | |
| Hydrochloric Acid SCHEMBL11382535 | 0.93 | HRH3 (0.40) | HRH3LTA4HCYP4F2CYP4A11 | |
| SCHEMBL3334122 | 0.85 | LTA4H (0.46) | HRH3LTA4HNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23530082 | 0.82 | HRH3 (0.40) | HRH3LTA4H | |
| SCHEMBL1758566 | 0.81 | ALDH1A1 (0.40) | HRH3LTA4H | |
| SCHEMBL11471063 | 0.81 | LTA4H (0.46) | HRH3LTA4HNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9334195 | 0.81 | NR5A1 (0.54) | LTA4HNPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL17544106 | 0.80 | CBFB (0.46) | HRH3LTA4H | |
| SCHEMBL29549754 | 0.80 | ATM (0.42) | HRH3LTA4H | |
| SCHEMBL23529948 | 0.80 | ATM (0.42) | HRH3LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4260620-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1981-04-07 | — | — | US | disclosed |
| US-4229448-A | 5-Substituted picolinic acid derivatives and an anti-hypertensive composition containing the same | MEUJI SEIKA KAISHA LTD. (JP) | 1980-10-21 | — | — | US | disclosed |
| US-4202901-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1980-05-13 | — | — | US | disclosed |
| US-4197302-A | HYPOTENSIVE AGENTS, 5-ETHERIFIED, ALSO ESTERS, AMIDES, HYDRAZIDES | CIBA-GEIGY CORPORATION (US) | 1980-04-08 | — | — | US | disclosed |