Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.58 |
| ▸ | PKM | P14618 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Picolinic Acid SCHEMBL11829119 | 0.83 | LMNA (0.67) | SMN1; SMN2PKMNPC1RAB9AGAA | |
| SCHEMBL11829134 | 0.80 | SMN1; SMN2 (0.64) | SMN1; SMN2PKMNPC1RAB9AGAA | |
| SCHEMBL14624343 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2PKMNPC1RAB9AGAA | |
| SCHEMBL15968945 | 0.80 | CTNNB1 (0.54) | SMN1; SMN2PKMNPC1RAB9AGAA | |
| SCHEMBL7932102 | 0.79 | ALDH1A1 (0.63) | SMN1; SMN2PKMNPC1RAB9ACYP1A2 | |
| SCHEMBL27993688 | 0.79 | SMN1; SMN2 (0.59) | SMN1; SMN2PKMNPC1RAB9AGAA | |
| SCHEMBL11517917 | 0.78 | KMT2A (0.51) | SMN1; SMN2PKMNPC1RAB9AGAA | |
| SCHEMBL31369148 | 0.78 | KMT2A (0.75) | SMN1; SMN2PKMNPC1RAB9AHTT | |
| SCHEMBL87791 | 0.78 | KMT2A (0.75) | SMN1; SMN2PKMNPC1RAB9AHTT | |
| SCHEMBL5292939 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2PKMNPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4297359-A | ANTISECRETORY AGENTS; GASTROINTESTINAL DISORDERS | ACF CHEMIEFARMA NV (NL) | 1981-10-27 | — | — | US | disclosed |
| EP-0007679-A1 | Oxime ethers, processes for their manufacture and pharmaceutical compositions thereof | ACF CHEMIEFARMA NV (NL) | 1980-02-06 | — | — | EP | disclosed |