Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 11/20 | 0.47 |
| ▸ | BACE1 | P56817 | 11/20 | 0.47 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 8/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11380203 | 1.00 | ACHE (0.47) | ACHEBACE1L3MBTL3L3MBTL1BCHE | |
| SCHEMBL11373892 | 0.90 | BACE1 (0.56) | ACHEBACE1L3MBTL3L3MBTL1BCHE | |
| SCHEMBL11373895 | 0.90 | BACE1 (0.56) | ACHEBACE1L3MBTL3L3MBTL1BCHE | |
| SCHEMBL11375571 | 0.89 | CNR1 (0.45) | ACHEBACE1L3MBTL3L3MBTL1BCHE | |
| SCHEMBL11375575 | 0.89 | CNR1 (0.45) | ACHEBACE1L3MBTL3L3MBTL1BCHE | |
| SCHEMBL11371337 | 0.88 | OPRM1 (0.45) | ACHEBACE1L3MBTL3L3MBTL1BCHE | |
| SCHEMBL11371342 | 0.88 | OPRM1 (0.45) | ACHEBACE1L3MBTL3L3MBTL1BCHE | |
| SCHEMBL11373880 | 0.84 | ACHE (0.62) | ACHEBACE1L3MBTL3L3MBTL1BCHE | |
| SCHEMBL11373876 | 0.84 | ACHE (0.62) | ACHEBACE1L3MBTL3L3MBTL1BCHE | |
| SCHEMBL11372229 | 0.80 | BACE1 (0.56) | ACHEBACE1L3MBTL3L3MBTL1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4267318-A | 1-(Diarylmethyl)-4-piperidinamine and derivatives thereof | G. D. SEARLE & CO. (US) | 1981-05-12 | — | — | US | claimed |
| US-4267318-A | 1-(Diarylmethyl)-4-piperidinamine and derivatives thereof | G. D. SEARLE & CO. (US) | 1981-05-12 | — | — | US | disclosed |