SCHEMBL11380839

SCHEMBL11380839

O=C=Nc1ccccc1SCl

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.47
TRPA1 O75762 1/20 0.33
TDP1 Q9NUW8 2/20 0.32
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
GABRA1 P14867 1/20 0.31
GABRB2 P47870 1/20 0.31
MAPK1 P28482 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11849635 0.83 HTR3E (0.30)
SCHEMBL29808667 0.83 CYP3A4 (0.50) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL29716699 0.83 CYP3A4 (0.50) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL10408265 0.83 CYP3A4 (0.50) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL8937141 0.83 CYP3A4 (0.50) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL623608 0.79 CYP3A4 (0.52) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL28264037 0.79 CYP3A4 (0.47) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL28766794 0.79 ALDH1A1 (0.47) CYP3A4TRPA1TDP1ALDH1A1HPGD
SCHEMBL19713002 0.77 CYP3A4 (0.41) CYP3A4TDP1HPGDMAPK1
SCHEMBL15431 0.77 CYP3A4 (0.64) CYP3A4TRPA1TDP1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0025500-A1 Process for producing an adhering polyurethane or polyurea elastomer film on shaped rubber articles METZELER KAUTSCHUK GMBH (DE) 1981-03-25 EP disclosed