Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfanilamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 13/20 | 0.73 |
| ▸ | CA2 | P00918 | 13/20 | 0.73 |
| ▸ | CA12 | O43570 | 11/20 | 0.73 |
| ▸ | CA9 | Q16790 | 11/20 | 0.73 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | IDO1 | P14902 | 1/20 | 0.59 |
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | CA7 | P43166 | 2/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58191 | 0.86 | CA1 (0.67) | CA1CA2CA12CA9PKM | |
| SCHEMBL28865482 | 0.86 | CA1 (0.67) | CA1CA2CA12CA9PKM | |
| Acetylsulfanilamide SCHEMBL359721 | 0.86 | CA1 (1.00) | CA1CA2CA12CA9PKM | |
| Acetylsulfanilamide SCHEMBL8043497 | 0.84 | CA1 (0.96) | CA1CA2CA12CA9PKM | |
| Acetylsulfanilamide SCHEMBL28550936 | 0.84 | CA1 (0.96) | CA1CA2CA12CA9PKM | |
| Acetylsulfanilamide SCHEMBL8190989 | 0.84 | CA1 (0.96) | CA1CA2CA12CA9PKM | |
| Benzene SCHEMBL7868495 | 0.82 | CA1 (0.62) | CA1CA2CA12CA9PKM | |
| Mono-N-Acetyl Dapsone SCHEMBL10920445 | 0.81 | PKM (1.00) | CA1CA2CA12CA9PKM | |
| Acetylsulfanilamide SCHEMBL17360801 | 0.80 | CA1 (0.86) | CA1CA2CA12CA9IDO1 | |
| SCHEMBL7530654 | 0.80 | PKM (0.75) | CA1CA2CA12CA9PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4246358-A | POLYSULFONAMIDE FOAMS | MONSANTO RESEARCH CORPORATION (US) | 1981-01-20 | — | — | US | disclosed |