Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 6/20 | 0.40 |
| ▸ | CNR1 | P21554 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1138609 | 0.89 | PPARG (0.47) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| SCHEMBL1138533 | 0.88 | HTR7 (0.46) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| SCHEMBL10970693 | 0.86 | KDM4E (0.48) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| SCHEMBL1138649 | 0.85 | PPARG (0.47) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| SCHEMBL1138424 | 0.85 | SIGMAR1 (0.50) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| Water SCHEMBL9501517 | 0.85 | KDM4E (0.47) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| Hydrochloric Acid SCHEMBL10936383 | 0.85 | KDM4E (0.47) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| Hydrochloric Acid SCHEMBL9485699 | 0.85 | KDM4E (0.47) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| SCHEMBL1138484 | 0.84 | PPARG (0.45) | PPARGPPARAHTR7SIGMAR1DRD2 | |
| SCHEMBL4588554 | 0.83 | HTR7 (0.52) | PPARGPPARAHTR7SIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448550-B1 | NITROGENOUS TETRAHYDROPYRIDYL-ALKYL-HETEROCYCLES WITH TNF ACTIVITY | SANOFI AVENTIS (FR) | 2011-02-23 | — | — | EP | claimed |
| US-7211578-B2 | Nitrogenous tetrahydropyridyl-alkyl-heterocycles with TNF activity | SANOFI-AVENTIS (FR) | 2007-05-01 | — | — | US | claimed |
| US-20050004132-A1 | Nitrogenous tetrahydropyridyl-alkyl-heterocycles with tnf activity | SANOFI-AVENTIS (FR) | 2005-01-06 | — | — | US | claimed |
| US-7211578-B2 | Nitrogenous tetrahydropyridyl-alkyl-heterocycles with TNF activity | SANOFI-AVENTIS (FR) | 2007-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004132-A1 | Nitrogenous tetrahydropyridyl-alkyl-heterocycles with tnf activity | TNF, TNFRSF1A, NFKBIA | PPARG 2582/4885PPARA 2193/4885HTR7 1941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.