Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10970693 | 0.93 | KDM4E (0.48) | HTR7DRD2DRD4DRD3PPARG | |
| SCHEMBL1138418 | 0.92 | PPARG (0.46) | HTR7DRD2DRD4DRD3PPARG | |
| Hydrochloric Acid SCHEMBL10936383 | 0.92 | KDM4E (0.47) | HTR7DRD2DRD4DRD3PPARG | |
| Water SCHEMBL9501517 | 0.92 | KDM4E (0.47) | HTR7DRD2DRD4DRD3PPARG | |
| Hydrochloric Acid SCHEMBL9485699 | 0.91 | KDM4E (0.47) | HTR7DRD2DRD4DRD3PPARG | |
| SCHEMBL1138424 | 0.90 | SIGMAR1 (0.50) | HTR7DRD2DRD4DRD3PPARG | |
| SCHEMBL4588554 | 0.88 | HTR7 (0.52) | HTR7DRD2DRD4DRD3PPARG | |
| SCHEMBL1138454 | 0.88 | PPARG (0.46) | HTR7DRD2DRD4DRD3PPARG | |
| SCHEMBL1138355 | 0.88 | PPARG (0.46) | HTR7DRD2DRD4DRD3PPARG | |
| SCHEMBL1138823 | 0.87 | PPARG (0.46) | HTR7DRD2DRD4DRD3PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448550-B1 | NITROGENOUS TETRAHYDROPYRIDYL-ALKYL-HETEROCYCLES WITH TNF ACTIVITY | SANOFI AVENTIS (FR) | 2011-02-23 | — | — | EP | claimed |
| US-7211578-B2 | Nitrogenous tetrahydropyridyl-alkyl-heterocycles with TNF activity | SANOFI-AVENTIS (FR) | 2007-05-01 | — | — | US | claimed |
| US-20050004132-A1 | Nitrogenous tetrahydropyridyl-alkyl-heterocycles with tnf activity | SANOFI-AVENTIS (FR) | 2005-01-06 | — | — | US | claimed |
| EP-1448550-A1 | NITROGENOUS TETRAHYDROPYRIDYL-ALKYL-HETEROCYCLES WITH TNF ACTIVITY | Sanofi-Aventis (FR) | 2004-08-25 | — | — | EP | claimed |
| WO-2003044010-A1 | NITROGENOUS TETRAHYDROPYRIDYL-ALKYL-HETEROCYCLES WITH TNF ACTIVITY | SANOFI-SYNTHELABO (FR) | 2003-05-30 | — | — | WO | claimed |
| EP-1448550-B1 | NITROGENOUS TETRAHYDROPYRIDYL-ALKYL-HETEROCYCLES WITH TNF ACTIVITY | SANOFI AVENTIS (FR) | 2011-02-23 | — | — | EP | disclosed |
| US-7211578-B2 | Nitrogenous tetrahydropyridyl-alkyl-heterocycles with TNF activity | SANOFI-AVENTIS (FR) | 2007-05-01 | — | — | US | disclosed |
| US-20050004132-A1 | Nitrogenous tetrahydropyridyl-alkyl-heterocycles with tnf activity | SANOFI-AVENTIS (FR) | 2005-01-06 | — | — | US | disclosed |
| EP-1448550-A1 | NITROGENOUS TETRAHYDROPYRIDYL-ALKYL-HETEROCYCLES WITH TNF ACTIVITY | Sanofi-Aventis (FR) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003044010-A1 | NITROGENOUS TETRAHYDROPYRIDYL-ALKYL-HETEROCYCLES WITH TNF ACTIVITY | SANOFI-SYNTHELABO (FR) | 2003-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004132-A1 | Nitrogenous tetrahydropyridyl-alkyl-heterocycles with tnf activity | TNF, TNFRSF1A, NFKBIA | HTR7 1941/4885DRD2 1380/4885DRD4 949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.