Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | HTR1B | P28222 | 2/20 | 0.55 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.52 |
| ▸ | HTR6 | P50406 | 3/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.51 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11499924 | 0.94 | HRH3 (0.50) | HTR1AHTR1BCHRNB4CHRNA3HRH3 | |
| Ammonia Solution, Strong SCHEMBL29771408 | 0.84 | HTR1D (0.49) | HTR1BCHRNB4CHRNA3HTR6 | |
| SCHEMBL11379154 | 0.83 | CHRNB4 (0.66) | HTR1AHTR1BCHRNB4CHRNA3HRH3 | |
| SCHEMBL13162975 | 0.81 | HTR1D (0.52) | HTR1BCHRNB4CHRNA3HRH3HTR6 | |
| SCHEMBL9414483 | 0.81 | CHRNB4 (0.49) | HTR1AHTR1BCHRNB4CHRNA3HRH3 | |
| SCHEMBL14421411 | 0.80 | CHRNB4 (0.56) | CHRNB4CHRNA3HTR6HRH1 | |
| SCHEMBL11373073 | 0.80 | CHRNB4 (0.56) | CHRNB4CHRNA3HTR6HRH1 | |
| SCHEMBL11376577 | 0.80 | HTR6 (0.48) | HTR1BHTR6CHRNB2 | |
| SCHEMBL11369857 | 0.80 | CHRNB2 (0.54) | HTR1AHTR1BCHRNB4CHRNA3HRH3 | |
| SCHEMBL11378305 | 0.80 | ADRA1A (0.50) | HTR1BCHRNB4CHRNA3HRH3HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |
| EP-1995241-B1 | Inhibitors of ion channels | ICAGEN INC (US) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008118758-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (GB) | 2008-10-02 | — | — | WO | disclosed |
| US-4279918-A | ANTIDEPRESSANTS, STIMULANTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK G.M.B.H. (DE) | 1981-07-21 | — | — | US | disclosed |