Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 4/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.38 |
| ▸ | KISS1R | Q969F8 | 4/20 | 0.37 |
| ▸ | KRAS | P01116 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL11385380 | 0.95 | CXCR4 (0.37) | KDM4EMEN1LMNAMPOMAPT | |
| Tryptophan SCHEMBL5969644 | 0.94 | GHSR (0.45) | KDM4EMEN1LMNAMPOMAPT | |
| Tryptophan SCHEMBL6803993 | 0.94 | GHSR (0.45) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL20636605 | 0.92 | KISS1R (0.40) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL28732069 | 0.92 | KISS1R (0.40) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL29249859 | 0.92 | KDM4E (0.43) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL29006655 | 0.90 | GHSR (0.46) | KDM4EMEN1LMNAMPOMAPT | |
| Tryptophan SCHEMBL28519250 | 0.89 | CXCR4 (0.42) | CXCR4 | |
| Dl-Tryptophan SCHEMBL28374332 | 0.88 | MEN1 (0.41) | KDM4EMEN1LMNAMPOMAPT | |
| Tryptophan SCHEMBL6839207 | 0.87 | MEN1 (0.44) | KDM4EMEN1LMNAMPOMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0026985-A1 | Dog food containing amino acid as palatability aid; method for preparing such a dog food | GAINES FOODS INC. (US) | 1981-04-15 | — | — | EP | disclosed |