Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KISS1R | Q969F8 | 13/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL20636605 | 1.00 | KISS1R (0.40) | KISS1RKDM4EMEN1LMNAMPO | |
| Tryptophan SCHEMBL11385378 | 0.92 | KDM4E (0.40) | KISS1RKDM4EMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL29006655 | 0.89 | GHSR (0.46) | KISS1RKDM4EMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL29232989 | 0.88 | KDM4E (0.44) | KDM4EMEN1LMNAMPOMAPT | |
| Tryptophan SCHEMBL27667773 | 0.88 | IL23R (0.44) | KISS1RGHSR | |
| Dl-Tryptophan SCHEMBL27149957 | 0.88 | KDM4E (0.51) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL28374332 | 0.88 | MEN1 (0.41) | KISS1RKDM4EMEN1LMNAMPO | |
| Tryptophan SCHEMBL28519250 | 0.87 | CXCR4 (0.42) | CXCR4 | |
| Leucine SCHEMBL11385380 | 0.87 | CXCR4 (0.37) | KISS1RKDM4EMEN1LMNAMPO | |
| Tryptophan SCHEMBL6803993 | 0.86 | GHSR (0.45) | KDM4EMEN1LMNAMPOMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108779452-B | Light-emitting enzyme protein | 国立研究开发法人产业技术综合研究所 | 2022-05-03 | — | — | CN | disclosed |