Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11385771 | 1.00 | PDE4B (0.39) | PDE4BKDM4EKMT2AGLAGAA | |
| SCHEMBL11387880 | 0.88 | RAB9A (0.34) | KDM4EKMT2AALDH1A1RAB9AMEN1 | |
| SCHEMBL11390757 | 0.88 | NPC1 (0.47) | PDE4BKDM4EKMT2AGLAGAA | |
| SCHEMBL11390761 | 0.88 | NPC1 (0.47) | PDE4BKDM4EKMT2AGLAGAA | |
| SCHEMBL11387876 | 0.88 | RAB9A (0.34) | KDM4EKMT2AALDH1A1RAB9AMEN1 | |
| SCHEMBL7125438 | 0.82 | CYP1A2 (0.47) | PDE4BKDM4EKMT2AGLAGAA | |
| SCHEMBL9693584 | 0.77 | ACHE (0.47) | PDE4BKDM4EKMT2AGLAGAA | |
| SCHEMBL2288150 | 0.75 | KDM4E (0.48) | KDM4EKMT2AGLAGAANPC1 | |
| SCHEMBL9686653 | 0.74 | ACHE (0.48) | KDM4EKMT2AGLAGAANPC1 | |
| SCHEMBL9686907 | 0.74 | ACHE (0.48) | KDM4EKMT2AGLAGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4273932-A | 4-Hydroxy-5,6,7,8-tetrahydroquinoline-3-carboxylic acids and derivatives | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1981-06-16 | — | — | US | claimed |
| US-4273932-A | 4-Hydroxy-5,6,7,8-tetrahydroquinoline-3-carboxylic acids and derivatives | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1981-06-16 | — | — | US | disclosed |