Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | GLA | P06280 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11390757 | 0.84 | NPC1 (0.47) | CYP1A2KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL11390761 | 0.84 | NPC1 (0.47) | CYP1A2KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL9693584 | 0.82 | ACHE (0.47) | CYP1A2KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL11385771 | 0.82 | PDE4B (0.39) | CYP1A2KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL11385772 | 0.82 | PDE4B (0.39) | CYP1A2KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL2288150 | 0.80 | KDM4E (0.48) | CYP1A2KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL11309257 | 0.79 | TDP1 (0.35) | CYP1A2CYP2C9KDM4EALDH1A1HSD17B10 | |
| SCHEMBL9687353 | 0.78 | ACHE (0.48) | CYP1A2KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL9686653 | 0.78 | ACHE (0.48) | CYP1A2KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL9686907 | 0.78 | ACHE (0.48) | CYP1A2KDM4EALDH1A1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4273932-A | 4-Hydroxy-5,6,7,8-tetrahydroquinoline-3-carboxylic acids and derivatives | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1981-06-16 | — | — | US | claimed |
| JP-55120566-A | — | — | None | — | — | JP | disclosed |
| US-20030219427-A1 | TPL-2/COT kinase and methods of use | MEDICAL RESEARCH COUNCIL (GB) | 2003-11-27 | — | — | US | disclosed |
| US-20020099169-A1 | TPL-2/COT KINASE AND METHODS OF USE | BASF AKTIENGESELLCHAFT | 2002-07-25 | — | — | US | disclosed |
| EP-1105501-A2 | TPL-2/COT KINASE AND METHODS OF USE | BASF Aktiengesellschaft (US) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000011191-A2 | TPL-2/COT KINASE AND METHODS OF USE | BASF AKTIENGESELLSCHAFT (US) | 2000-03-02 | — | — | WO | disclosed |
| US-4296112-A | ANTIBACTERIAL | MITSUI TOATSU CHEMICALS, INC. (JP) | 1981-10-20 | — | — | US | disclosed |
| US-4283398-A | Cephalosporins | MITSUI TOATSU CHEMICALS, INC. (JP) | 1981-08-11 | — | — | US | disclosed |
| US-4273932-A | 4-Hydroxy-5,6,7,8-tetrahydroquinoline-3-carboxylic acids and derivatives | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1981-06-16 | — | — | US | disclosed |
| US-4263302-A | ANTIBIOTICS EFFECTIVE AGAINST PSEUDOMONAS | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1981-04-21 | — | — | US | disclosed |
| US-4246270-A | TRANQUILIZERS, MUSCLE RELAXANTS, AND SEDATIVES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-01-20 | — | — | US | disclosed |
| JP-S55120566-A | NEW QUINOLINE DERIVATIVE | MITSUI TOATSU CHEM INC | 1980-09-17 | — | — | JP | disclosed |
| US-4120856-A | REACTING 3-HYDROXY-BENZODIAZEPINES WITH AMINOSULFUR TRIFLUORIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1978-10-17 | — | — | US | disclosed |