Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 9/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6280310 | 0.79 | KDM4E (0.46) | KDM4EHSD17B10NOTUMPOLBALDH1A1 | |
| SCHEMBL6280307 | 0.73 | KDM4E (0.57) | KDM4EHSD17B10PIM1ALDH1A1CYP1A2 | |
| SCHEMBL11392116 | 0.72 | HSD17B10 (0.47) | KDM4EHSD17B10PIM1ALDH1A1CYP1A2 | |
| SCHEMBL10594428 | 0.71 | PIM1 (0.46) | KDM4EHSD17B10PIM1ALDH1A1CYP1A2 | |
| SCHEMBL27800425 | 0.71 | KDM4E (0.48) | KDM4EHSD17B10NOTUMPOLBALDH1A1 | |
| SCHEMBL12832618 | 0.70 | NPC1 (0.47) | KDM4EHSD17B10POLBALDH1A1CYP1A2 | |
| SCHEMBL11158748 | 0.69 | SCN5A (0.55) | KDM4EHSD17B10NOTUMPIM1ALDH1A1 | |
| SCHEMBL11465545 | 0.69 | BRD9 (0.53) | KDM4EHSD17B10KMODYRK1ADYRK2 | |
| SCHEMBL11625891 | 0.69 | ALDH1A1 (0.59) | KDM4EHSD17B10POLBALDH1A1CYP1A2 | |
| SCHEMBL10595206 | 0.69 | JAK2 (0.46) | KDM4EHSD17B10PIM1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4269980-A | TRANQUILIZERS; ANTICONVULSANTS | AMERICAN CYANAMID COMPANY (US) | 1981-05-26 | — | — | US | claimed |
| US-4269980-A | TRANQUILIZERS; ANTICONVULSANTS | AMERICAN CYANAMID COMPANY (US) | 1981-05-26 | — | — | US | disclosed |