Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | IDH2 | P48735 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 7/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11392116 | 0.85 | HSD17B10 (0.47) | KDM4EHSD17B10ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL10594428 | 0.81 | PIM1 (0.46) | JAK2KDM4EHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL10855490 | 0.80 | IDH2 (0.44) | JAK2IDH2PIM1PLK1PLK3 | |
| SCHEMBL10594636 | 0.76 | KMO (0.42) | JAK2KDM4EHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL10596818 | 0.74 | KDM4E (0.44) | JAK2KDM4EALDH1A1PIM1DYRK1A | |
| SCHEMBL21116043 | 0.73 | CSNK1A1 (0.58) | IDH2KDM4EALDH1A1PLK1KDR | |
| SCHEMBL3216817 | 0.73 | JAK2 (0.70) | JAK2DYRK1ADYRK2GSK3BJAK3 | |
| SCHEMBL3300957 | 0.70 | JAK2 (0.50) | JAK2KDM4EALDH1A1PLK1KDR | |
| SCHEMBL10596220 | 0.69 | NOS3 (0.38) | JAK2KDM4EHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL11386388 | 0.69 | KDM4E (0.54) | KDM4EHSD17B10ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4579848-A | ANTIASTHMA AGENTS | AMERICAN CYANAMID COMPANY (US) | 1986-04-01 | — | — | US | claimed |
| EP-0132851-B1 | 5-SUBSTITUTED(1,2,4)TRIAZOLO(1,5-C)PYRIMIDIN-2-AMINES | AMERICAN CYANAMID COMPANY (US) | 1989-10-04 | — | — | EP | disclosed |
| EP-0132851-A1 | 5-Substituted(1,2,4)triazolo(1,5-c)pyrimidin-2-amines | AMERICAN CYANAMID COMPANY (US) | 1985-02-13 | — | — | EP | disclosed |