Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6280307 | 0.83 | KDM4E (0.57) | KDM4EHSD17B10NPC1RAB9AMAPK14 | |
| SCHEMBL11386388 | 0.79 | KDM4E (0.54) | KDM4EHSD17B10ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6277021 | 0.75 | BCHE (0.39) | KDM4EHSD17B10NPC1RAB9AMAPK14 | |
| SCHEMBL6279167 | 0.75 | KDR (0.39) | KDM4ERAB9AHPGD | |
| SCHEMBL3881826 | 0.71 | KIF11 (0.67) | NPC1RAB9AMAPK14MAPK13RAF1 | |
| SCHEMBL9725474 | 0.69 | NPC1 (0.50) | KDM4EHSD17B10NPC1RAB9AMAPK14 | |
| SCHEMBL5788335 | 0.68 | MAPK11 (0.42) | KDM4EHSD17B10NPC1RAB9AMAPK14 | |
| SCHEMBL1925218 | 0.68 | NPC1 (0.44) | KDM4ENPC1RAB9AMAPK14MAPK13 | |
| SCHEMBL11625891 | 0.67 | ALDH1A1 (0.59) | KDM4EHSD17B10NPC1ALDH1A1CYP1A2 | |
| SCHEMBL17014793 | 0.65 | KDM4E (0.69) | KDM4ENPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921762-B2 | Substituted indolizine-like compounds and methods of use | AMGEN INC. (US) | 2005-07-26 | — | — | US | disclosed |