SCHEMBL11387955

SCHEMBL11387955

C[C](C)C(=O)c1sc(-c2cccnc2)nc1C

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.73
CYP3A4 P08684 4/20 0.73
CYP2C19 P33261 3/20 0.73
LMNA P02545 1/20 0.73
KMT2A Q03164 4/20 0.60
MEN1 O00255 3/20 0.60
CYP2D6 P10635 1/20 0.60
CYP2C9 P11712 1/20 0.60
MAPT P10636 4/20 0.57
KDM4E B2RXH2 4/20 0.53
SMN1; SMN2 Q16637 2/20 0.52
BRAF P15056 1/20 0.50
CDC7 O00311 2/20 0.49
DBF4 Q9UBU7 2/20 0.49
ALDH1A1 P00352 4/20 0.49
HPGD P15428 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
GFER P55789 1/20 0.47
HDAC3 O15379 1/20 0.47
HDAC1 Q13547 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29783018 0.89 CYP3A4 (0.77) CYP1A2CYP3A4CYP2C19LMNAKMT2A
SCHEMBL1574577 0.89 CYP3A4 (0.77) CYP1A2CYP3A4CYP2C19LMNAKMT2A
Hydrochloric Acid SCHEMBL1679765 0.87 CYP3A4 (0.75) CYP1A2CYP3A4CYP2C19LMNAKMT2A
SCHEMBL595294 0.86 CYP1A2 (0.77) CYP1A2CYP3A4CYP2C19LMNAKMT2A
Hydrochloric Acid SCHEMBL11388179 0.84 CYP1A2 (0.75) CYP1A2CYP3A4CYP2C19LMNAKMT2A
SCHEMBL5211666 0.84 CYP1A2 (1.00) CYP1A2CYP3A4CYP2C19LMNAKMT2A
SCHEMBL3065347 0.84 CYP1A2 (0.75) CYP1A2CYP3A4CYP2C19LMNAKMT2A
Hydrochloric Acid SCHEMBL11388173 0.83 CYP1A2 (0.73) CYP1A2CYP3A4CYP2C19LMNAKMT2A
SCHEMBL11389733 0.83 CYP1A2 (1.00) CYP1A2CYP3A4CYP2C19LMNAKMT2A
SCHEMBL10066961 0.83 CYP3A4 (0.68) CYP1A2CYP3A4CYP2C19LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4260765-A APHIDICIDES UNIROYAL, INC. (US) 1981-04-07 US disclosed
US-4080457-A INSECTICIDES, PESTICIDES, MITICIDES UNIROYAL CHEMICAL COMPANY, INC. 1978-03-21 US disclosed