Sugi Predict

Sugi Predict / Compounds / SCHEMBL595294

SCHEMBL595294

SCHEMBL595294

Cc1nc(-c2cccnc2)sc1C(=O)O

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 4/20 0.77
▸ CYP3A4 P08684 4/20 0.77
▸ CYP2C19 P33261 3/20 0.77
▸ LMNA P02545 1/20 0.77
▸ SMN1; SMN2 Q16637 4/20 0.72
▸ KMT2A Q03164 4/20 0.62
▸ MEN1 O00255 3/20 0.62
▸ CYP2D6 P10635 1/20 0.62
▸ CYP2C9 P11712 1/20 0.62
▸ KDM4E B2RXH2 6/20 0.61
▸ RAB9A P51151 3/20 0.61
▸ GAA P10253 2/20 0.61
▸ MAPT P10636 3/20 0.59
▸ NPC1 O15118 1/20 0.58
▸ POLB P06746 1/20 0.58
▸ ALDH1A1 P00352 3/20 0.56
▸ HPGD P15428 1/20 0.55
▸ NPSR1 Q6W5P4 1/20 0.55
▸ GPR35 Q9HC97 1/20 0.54
▸ CDC7 O00311 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11388179 0.99 CYP1A2 (0.75) CYP1A2CYP3A4CYP2C19LMNASMN1; SMN2
SCHEMBL289879 0.89 CYP3A4 (0.62) CYP1A2CYP3A4CYP2C19LMNASMN1; SMN2
SCHEMBL29783018 0.88 CYP3A4 (0.77) CYP1A2CYP3A4CYP2C19LMNASMN1; SMN2
SCHEMBL1574577 0.88 CYP3A4 (0.77) CYP1A2CYP3A4CYP2C19LMNASMN1; SMN2
SCHEMBL3065347 0.87 CYP1A2 (0.75) CYP1A2CYP3A4CYP2C19LMNASMN1; SMN2
SCHEMBL5211666 0.87 CYP1A2 (1.00) CYP1A2CYP3A4CYP2C19LMNASMN1; SMN2
Hydrochloric Acid SCHEMBL1679765 0.87 CYP3A4 (0.75) CYP1A2CYP3A4CYP2C19LMNASMN1; SMN2
SCHEMBL11387955 0.86 CYP1A2 (0.73) CYP1A2CYP3A4CYP2C19LMNASMN1; SMN2
SCHEMBL11389733 0.86 CYP1A2 (1.00) CYP1A2CYP3A4CYP2C19LMNASMN1; SMN2
Hydrochloric Acid SCHEMBL11388173 0.86 CYP1A2 (0.73) CYP1A2CYP3A4CYP2C19LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 141 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3197276-B1 HERBICIDAL PYRIDINO-/PYRIMIDINO-THIAZOLES SYNGENTA PARTICIPATIONS AG (CH) 2023-06-07 — — EP disclosed
EP-3197276-B1 HERBICIDAL PYRIDINO-/PYRIMIDINO-THIAZOLES SYNGENTA PARTICIPATIONS AG (CH) 2023-06-07 — — EP disclosed
US-11470846-B2 Herbicidal pyridino-/pyrimidino-thiazoles SYNGENTA PARTICIPATIONS AG (CH) 2022-10-18 — — US disclosed
CN-107001349-B Herbicidal pyrido/pyrimidothiazoles 先正达参股股份有限公司 2021-07-02 — — CN disclosed
US-20200253208-A1 HERBICIDAL PYRIDINO-/PYRIMIDINO-THIAZOLES SYNGENTA PARTICIPATIONS AG (CH) 2020-08-13 — — US disclosed
US-20200253208-A1 HERBICIDAL PYRIDINO-/PYRIMIDINO-THIAZOLES SYNGENTA PARTICIPATIONS AG (CH) 2020-08-13 — — US disclosed
US-20180206498-A1 SUBSTITUTED HETEROARYL CARBOXYLIC ACID HYDRAZIDES OR SALTS THEREOF AND USE THEREOF TO INCREASE STRESS TOLERANCE IN PLANTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-07-26 — — US disclosed
EP-3325467-A1 SUBSTITUTED HETEROARYL CARBOXYLIC ACID HYDRAZIDES OR SALTS THEREOF AND USE THEREOF TO INCREASE STRESS TOLERANCE IN PLANTS Bayer CropScience Aktiengesellschaft (DE) 2018-05-30 — — EP disclosed
EP-2935271-B1 NOVEL SUBSTITUTED IMIDAZOLES AS CASEIN KINASE 1 / INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2017-10-25 — — EP disclosed
US-20170290337-A1 Herbicidal Pyridino-/Pyrimidino-Thiazoles SYNGENTA PARTICIPATIONS AG (CH) 2017-10-12 — — US disclosed
US-20040082079-A1 Low affinity screening method GRAFFINITY PHARMACEUTICALS AG. (DE) 2004-04-29 — — US disclosed
CN-1492874-A Macrolide antibiotics — 2004-04-28 — — CN disclosed
EP-1360489-A1 LOW AFFINITY SCREENING METHOD Graffinity Pharmaceuticals Aktiengesellschaft (DE) 2003-11-12 — — EP disclosed
WO-2003032971-A1 5’-ACYLAMINO-1,1’-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS GLAXO GROUP LIMITED (GB) 2003-04-24 — — WO disclosed
WO-2002063299-A1 LOW AFFINITY SCREENING METHOD GRAFFINITY PHARMACEUTICALS AG (DE) 2002-08-15 — — WO disclosed
US-6359134-B1 ANTICOAGULANTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-03-19 — — US disclosed
EP-0986551-A1 SULFONAMIDE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Pharmaceutical Company Limited (JP) 2000-03-22 — — EP disclosed
WO-1998054164-A1 SULFONAMIDE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-12-03 — — WO disclosed
US-4260765-A APHIDICIDES UNIROYAL, INC. (US) 1981-04-07 — — US disclosed
US-4080457-A INSECTICIDES, PESTICIDES, MITICIDES UNIROYAL CHEMICAL COMPANY, INC. 1978-03-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170290337-A1 Herbicidal Pyridino-/Pyrimidino-Thiazoles PDXK, PLPBP, DDT CYP1A2 136/4885CYP3A4 716/4885CYP2C19 406/4885
US-11470846-B2 Herbicidal pyridino-/pyrimidino-thiazoles PDXK, PLPBP, DDT CYP1A2 136/4885CYP3A4 716/4885CYP2C19 406/4885
US-20200253208-A1 HERBICIDAL PYRIDINO-/PYRIMIDINO-THIAZOLES PDXK, PLPBP, DDT CYP1A2 136/4885CYP3A4 716/4885CYP2C19 406/4885
US-20180206498-A1 SUBSTITUTED HETEROARYL CARBOXYLIC ACID HYDRAZIDES OR SALTS THEREOF AND USE THEREOF TO INCREASE STRESS TOLERANCE IN PLANTS GRHPR, HACL2, PAH CYP1A2 278/4885CYP3A4 472/4885CYP2C19 633/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.