Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | CDC7 | O00311 | 3/20 | 0.50 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL595294 | 0.87 | CYP1A2 (0.77) | CYP1A2CYP3A4CYP2C19LMNAMEN1 | |
| SCHEMBL29783018 | 0.87 | CYP3A4 (0.77) | CYP1A2CYP3A4CYP2C19LMNAMEN1 | |
| SCHEMBL1574577 | 0.87 | CYP3A4 (0.77) | CYP1A2CYP3A4CYP2C19LMNAMEN1 | |
| Hydrochloric Acid SCHEMBL1679765 | 0.86 | CYP3A4 (0.75) | CYP1A2CYP3A4CYP2C19LMNAMEN1 | |
| Hydrochloric Acid SCHEMBL11388179 | 0.86 | CYP1A2 (0.75) | CYP1A2CYP3A4CYP2C19LMNAMEN1 | |
| SCHEMBL3065347 | 0.86 | CYP1A2 (0.75) | CYP1A2CYP3A4CYP2C19LMNAMEN1 | |
| Hydrochloric Acid SCHEMBL11388173 | 0.84 | CYP1A2 (0.73) | CYP1A2CYP3A4CYP2C19LMNAMEN1 | |
| SCHEMBL11389733 | 0.84 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C19LMNAMEN1 | |
| SCHEMBL11387955 | 0.84 | CYP1A2 (0.73) | CYP1A2CYP3A4CYP2C19LMNAMEN1 | |
| SCHEMBL8024677 | 0.83 | CYP1A2 (0.71) | CYP1A2CYP3A4CYP2C19LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10611776-B2 | Spiroheptane salicylamides and related compounds as inhibitors of rock | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-04-07 | — | — | US | disclosed |
| US-20190016735-A1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2019-01-17 | — | — | US | disclosed |
| US-20160316755-A1 | Novel Heteroaromatic Amides and Thioamides as Pesticides | BAYER CROPSCIENCE AG (DE) | 2016-11-03 | — | — | US | disclosed |
| US-9428487-B2 | Heteroaromatic amides and thioamides as pesticides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-08-30 | — | — | US | disclosed |
| EP-1363925-B8 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LTD (GB) | 2007-04-25 | — | — | EP | disclosed |
| EP-1363925-B1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LTD (GB) | 2006-11-15 | — | — | EP | disclosed |
| US-20060211636-A1 | Macrolide Antibiotics | ALIHODZIC SULEJMAN | 2006-09-21 | — | — | US | disclosed |
| US-20050215495-A1 | Macrolide antibiotics | ALIHODZIC SULEJMAN | 2005-09-29 | — | — | US | disclosed |
| US-20040077557-A1 | Macrolide antibiotics | GLAXO GROUP LIMITED (GB) | 2004-04-22 | — | — | US | disclosed |
| EP-1363925-A1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LIMITED (GB) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002050091-A1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LIMITED (GB) | 2002-06-27 | — | — | WO | disclosed |
| US-4260765-A | APHIDICIDES | UNIROYAL, INC. (US) | 1981-04-07 | — | — | US | disclosed |
| US-4080457-A | INSECTICIDES, PESTICIDES, MITICIDES | UNIROYAL CHEMICAL COMPANY, INC. | 1978-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160316755-A1 | Novel Heteroaromatic Amides and Thioamides as Pesticides | AADAC, DDT, TST | CYP1A2 254/4885CYP3A4 399/4885CYP2C19 1984/4885 |
| US-20050215495-A1 | Macrolide antibiotics | IL1R1, MRPL12, RPS21 | CYP1A2 375/4885CYP3A4 341/4885CYP2C19 209/4885 |
| US-20060211636-A1 | Macrolide Antibiotics | IL1R1, MRPL12, RPS21 | CYP1A2 375/4885CYP3A4 341/4885CYP2C19 209/4885 |
| US-20190016735-A1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | ROCK1, MYLK, RHOA | CYP1A2 1849/4885CYP3A4 3175/4885CYP2C19 2557/4885 |
| US-10611776-B2 | Spiroheptane salicylamides and related compounds as inhibitors of rock | ROCK1, MYLK, RHOA | CYP1A2 1849/4885CYP3A4 3175/4885CYP2C19 2557/4885 |
| US-20040077557-A1 | Macrolide antibiotics | MALT1, MRPL21, IL1R1 | CYP1A2 362/4885CYP3A4 500/4885CYP2C19 380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.