SCHEMBL11388643

SCHEMBL11388643

COc1ccc(/C=C/C=C/C(=O)C2CC2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 2/20 0.57
HDAC6 Q9UBN7 2/20 0.57
STAT3 P40763 1/20 0.57
F3 P13726 3/20 0.54
MAOB P27338 5/20 0.53
THRB P10828 1/20 0.53
ATM Q13315 1/20 0.53
MAOA P21397 2/20 0.52
CYP1A2 P05177 1/20 0.52
CYP2D6 P10635 1/20 0.52
GSK3B P49841 1/20 0.51
RAB9A P51151 3/20 0.50
NPC1 O15118 2/20 0.50
ALDH1A1 P00352 2/20 0.50
HDAC3 O15379 1/20 0.50
HDAC1 Q13547 1/20 0.50
HDAC2 Q92769 1/20 0.50
TRPM8 Q7Z2W7 1/20 0.50
MAPT P10636 2/20 0.49
XDH P47989 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11388645 1.00 HDAC8 (0.57) HDAC8HDAC6STAT3F3MAOB
SCHEMBL11393308 0.89 F3 (0.64) HDAC8HDAC6F3MAOBTHRB
SCHEMBL11393305 0.89 F3 (0.64) HDAC8HDAC6F3MAOBTHRB
SCHEMBL10669348 0.82 TRPM8 (0.64) HDAC8HDAC6F3MAOBTHRB
SCHEMBL25307242 0.81 THRB (0.74) HDAC8HDAC6STAT3F3MAOB
SCHEMBL25853463 0.80 GSK3B (0.61) HDAC8HDAC6STAT3F3MAOB
SCHEMBL25853466 0.80 HDAC8 (0.66) HDAC8HDAC6STAT3F3MAOB
SCHEMBL2026113 0.79 HDAC8 (0.65) HDAC8HDAC6STAT3F3MAOB
SCHEMBL2026112 0.79 HDAC8 (0.65) HDAC8HDAC6STAT3F3MAOB
SCHEMBL1231605 0.79 THRB (0.77) HDAC8HDAC6STAT3F3MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4182729-A Arylvinyl cyclopropyl ketones STERLING DRUG INC. (US) 1980-01-08 US claimed
US-4275201-A Aryl substituted diketones STERLING DRUG INC. (US) 1981-06-23 US disclosed
US-4227015-A Substituted phenylvinyl cyclopropyl ketones STERLING DRUG INC. (US) 1980-10-07 US disclosed
US-4189500-A VIRICIDES STERLING DRUG INC. (US) 1980-02-19 US disclosed
US-4182729-A Arylvinyl cyclopropyl ketones STERLING DRUG INC. (US) 1980-01-08 US disclosed
US-4171378-A INSECTICIDES, VIRICIDES STERLING DRUG INC. (US) 1979-10-16 US disclosed
US-4166074-A DIALKYLAMINOPHENYLETHYL (OR VINYL) CYCLOPROPYL CARBINOLS STERLING DRUG INC. (US) 1979-08-28 US disclosed