Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 3/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1375300 | 0.82 | NPC1 (0.48) | SMN1; SMN2BRD4MAPTKDM4ENPC1 | |
| SCHEMBL11400411 | 0.82 | TSHR (0.45) | SMN1; SMN2BRD4MAPTKDM4ELTA4H | |
| SCHEMBL11406560 | 0.81 | HRH3 (0.53) | SMN1; SMN2KDM4ELTA4HTSHRKCNH2 | |
| SCHEMBL1373452 | 0.78 | HRH3 (0.49) | BRD4KCNH2 | |
| SCHEMBL22130216 | 0.76 | BRD4 (0.48) | SMN1; SMN2BRD4MAPTNPC1RAB9A | |
| SCHEMBL11396609 | 0.75 | BRD4 (0.47) | SMN1; SMN2BRD4MAPTNPC1RAB9A | |
| SCHEMBL11254410 | 0.74 | BRD4 (0.49) | BRD4MAPT | |
| SCHEMBL19659892 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTKDM4EPTGS1PTGS2 | |
| SCHEMBL11399262 | 0.73 | ALPL (0.48) | MAPTLTA4HSLC2A1NPC1RAB9A | |
| SCHEMBL22130283 | 0.73 | BRD4 (0.48) | BRD4MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4289774-A | Lipid lowering and anti-thrombotic 6-arylpyridazin-3-ones and a process for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-09-15 | — | — | US | disclosed |
| EP-0010156-A1 | 6-Arylpyridazine-3-ones, pharmaceutical compositions containing them and process for their preparation | MERCK PATENT GmbH (DE) | 1980-04-30 | — | — | EP | disclosed |