Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1753098 | 0.91 | ALPL (0.53) | ALPLMAPTHRH3NPC1RAB9A | |
| SCHEMBL11402579 | 0.90 | ALPL (0.51) | ALPLMAPTHRH3NPC1RAB9A | |
| SCHEMBL11397991 | 0.86 | NPC1 (0.54) | ALPLMAPTLTA4HHRH3NPC1 | |
| SCHEMBL11398355 | 0.86 | MAPT (0.52) | ALPLMAPTHRH3NPC1RAB9A | |
| SCHEMBL1376033 | 0.82 | GSK3A (0.63) | ALPLMAPTHRH3NPC1RAB9A | |
| SCHEMBL1752841 | 0.75 | ALPL (0.54) | ALPLMAPTHRH3NPC1RAB9A | |
| SCHEMBL22130300 | 0.75 | ALPL (0.53) | ALPLMAPTHRH3NPC1RAB9A | |
| SCHEMBL11396912 | 0.75 | L3MBTL1 (0.58) | ALPLMAPTHRH3RAB9AGSK3B | |
| SCHEMBL17016671 | 0.75 | MAPT (0.59) | ALPLMAPTHRH3NPC1RAB9A | |
| SCHEMBL1754740 | 0.75 | L3MBTL1 (0.61) | MAPTRAB9AMEN1KMT2AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4289774-A | Lipid lowering and anti-thrombotic 6-arylpyridazin-3-ones and a process for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-09-15 | — | — | US | disclosed |
| EP-0010156-A1 | 6-Arylpyridazine-3-ones, pharmaceutical compositions containing them and process for their preparation | MERCK PATENT GmbH (DE) | 1980-04-30 | — | — | EP | disclosed |