Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11403511 | 0.91 | GABRA1 (0.39) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11397278 | 0.87 | GABRA1 (0.36) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11397160 | 0.86 | TLR8 (0.46) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11546690 | 0.86 | GABRA1 (0.37) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11403505 | 0.83 | BRD4 (0.34) | TLR8CYP11B2 | |
| SCHEMBL11403673 | 0.83 | GABRA1 (0.53) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11397293 | 0.77 | CYP11B2 (0.38) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11402978 | 0.76 | CYP11B2 (0.40) | CYP11B2 | |
| SCHEMBL11402761 | 0.74 | TLR8 (0.46) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11401211 | 0.74 | GABRA1 (0.44) | GABRA1GABRA5GABRA2GABRB2GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4296239-A | Amino-4H-s-triazolo[4,3-a][1,4]benzodiazepines | THE UPJOHN COMPANY (US) | 1981-10-20 | — | — | US | disclosed |
| US-4180668-A | Piperidino-4H-s-triazolo[4,3-a][1,4]benzodiazepines | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |