Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 7/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | PTAFR | P25105 | 4/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11403673 | 0.86 | GABRA1 (0.53) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11394966 | 0.85 | PTAFR (0.41) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11400803 | 0.85 | BRD4 (0.52) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11397293 | 0.83 | CYP11B2 (0.38) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11401666 | 0.82 | BRD4 (0.50) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11397278 | 0.81 | GABRA1 (0.36) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11406794 | 0.81 | PARP10 (0.37) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL16963490 | 0.80 | GABRA1 (0.54) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11574324 | 0.77 | BRD4 (0.44) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11396361 | 0.74 | GABRG2 (0.41) | GABRA1GABRA5GABRA2GABRB2GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4296239-A | Amino-4H-s-triazolo[4,3-a][1,4]benzodiazepines | THE UPJOHN COMPANY (US) | 1981-10-20 | — | — | US | disclosed |
| US-4180668-A | Piperidino-4H-s-triazolo[4,3-a][1,4]benzodiazepines | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |