Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CYP2E1 | P05181 | 3/20 | 0.31 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.31 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 2/20 | 0.30 |
| ▸ | CDC25B | P30305 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10844730 | 0.71 | PDE3B (0.41) | CDK8CYP2D6CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL11228219 | 0.68 | KCNH2 (0.46) | CCNCCDK8CYP2D6CYP2C19CYP1A2 | |
| SCHEMBL16827937 | 0.67 | CCNC (0.44) | CCNCCDK8CYP2E1CYP2D6CYP2A6 | |
| SCHEMBL11399450 | 0.67 | VHL (0.39) | CYP2C19CYP1A2CYP2C9METAP2CDC25B | |
| SCHEMBL11240696 | 0.67 | LMNA (0.42) | CCNCCDK8KDM5AMAOAMAOB | |
| SCHEMBL19441232 | 0.67 | CYP2C19 (0.49) | CCNCCDK8MAOAMAOBCYP2E1 | |
| SCHEMBL19601134 | 0.67 | CCNC (0.54) | CCNCCDK8CYP2E1CYP2C8CYP2D6 | |
| SCHEMBL12811202 | 0.65 | CCNC (0.45) | CCNCCDK8CYP2E1CYP2C8CYP2D6 | |
| SCHEMBL14927060 | 0.64 | CCNC (0.51) | CCNCCDK8MAOAMAOBCYP2E1 | |
| SCHEMBL11448518 | 0.64 | CCNC (0.58) | CCNCCDK8KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4304777-A | 6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |