Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17103800 | 0.74 | — | — | |
| SCHEMBL3421959 | 0.69 | MKNK1 (0.52) | VHLMKNK1MKNK2PDE3AELANE | |
| SCHEMBL31469002 | 0.69 | MKNK1 (0.52) | VHLMKNK1MKNK2PDE3AELANE | |
| SCHEMBL11398844 | 0.67 | CCNC (0.40) | METAP2CYP1A2CYP2C9CYP2C19CDC25B | |
| SCHEMBL10844730 | 0.66 | PDE3B (0.41) | MKNK1MKNK2PDE3APDE3BPDE4D | |
| SCHEMBL11254453 | 0.66 | SMN1; SMN2 (0.50) | VHLPDE3APDE3BPDE2APDE4D | |
| SCHEMBL11242504 | 0.65 | LMNA (0.49) | VHLMKNK1MKNK2PRMT5WDR77 | |
| SCHEMBL15730139 | 0.64 | GRIA1 (0.67) | PRMT5WDR77PDE3APDE3BPDE4D | |
| SCHEMBL15730874 | 0.64 | GSK3B (0.50) | BRD4 | |
| SCHEMBL30190467 | 0.64 | CLK4 (0.51) | VHLMKNK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4304777-A | 6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |