Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18826405 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL18826410 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL28500884 | 0.96 | ROCK2 (0.93) | ROCK2ROCK1 | |
| SCHEMBL21412770 | 0.96 | ROCK2 (0.93) | ROCK2ROCK1 | |
| SCHEMBL21412771 | 0.96 | ROCK2 (0.93) | ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL29192357 | 0.94 | ROCK2 (0.90) | ROCK2ROCK1 | |
| SCHEMBL20429343 | 0.93 | ROCK2 (0.87) | ROCK2ROCK1 | |
| SCHEMBL19154156 | 0.93 | ROCK2 (0.87) | ROCK2ROCK1 | |
| SCHEMBL13074900 | 0.91 | ROCK2 (0.87) | ROCK2ROCK1 | |
| SCHEMBL18826406 | 0.91 | ROCK2 (0.83) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3773580-A1 | MONO-(ACID) SALTS OF 6-AMINOISOQUINOLINES AND USES THEREOF | Aerie Pharmaceuticals, Inc. (US) | 2021-02-17 | — | — | EP | claimed |
| US-20190322625-A1 | MONO-(ACID) SALTS OF 6-AMINOISOQUINOLINES AND USES THEREOF | ALCON INC. (CH) | 2019-10-24 | — | — | US | claimed |
| WO-2019191654-A1 | MONO-(ACID) SALTS OF 6-AMINOISOQUINOLINES AND USES THEREOF | AERIE PHARMACEUTICALS, INC. (US) | 2019-10-03 | — | — | WO | claimed |
| EP-3053913-B1 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | AERIE PHARMACEUTICALS INC (US) | 2018-03-07 | — | — | EP | claimed |
| EP-3053913-A1 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | AERIE PHARMACEUTICALS, INC. (US) | 2016-08-10 | — | — | EP | claimed |
| EP-2424842-A2 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | Aerie Pharmaceuticals, Inc. (US) | 2012-03-07 | — | — | EP | claimed |
| WO-2010126626-A2 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | AERIE PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | claimed |
| US-20220144778-A1 | MONO-(ACID) SALTS OF 6-AMINOISOQUINOLINES AND USES THEREOF | ALCON INC. (CH) | 2022-05-12 | — | — | US | disclosed |
| US-20220144778-A1 | MONO-(ACID) SALTS OF 6-AMINOISOQUINOLINES AND USES THEREOF | ALCON INC. (CH) | 2022-05-12 | — | — | US | disclosed |
| US-20210363141-A1 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | ALCON INC. (CH) | 2021-11-25 | — | — | US | disclosed |
| US-11028081-B2 | Dual mechanism inhibitors for the treatment of disease | AERIE PHARMACEUTICALS, INC. (US) | 2021-06-08 | — | — | US | disclosed |
| US-11028081-B2 | Dual mechanism inhibitors for the treatment of disease | AERIE PHARMACEUTICALS, INC. (US) | 2021-06-08 | — | — | US | disclosed |
| EP-3828172-A1 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | Aerie Pharmaceuticals, Inc. (US) | 2021-06-02 | — | — | EP | disclosed |
| US-8394826-B2 | Dual mechanism inhibitors for the treatment of disease | AERIE PHARMACEUTICALS, INC. (US) | 2013-03-12 | — | — | US | disclosed |
| EP-2424842-A2 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | Aerie Pharmaceuticals, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| US-20100280011-A1 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | ALCON INC. (CH) | 2010-11-04 | — | — | US | disclosed |
| WO-2010127330-A1 | DUAL-ACTION INHIBITORS AND METHODS OF USING SAME | AERIE PHAMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010127329-A1 | DUAL-ACTION INHIBITORS AND METHODS OF USING SAME | AERIE PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126626-A2 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | AERIE PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126626-A2 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | AERIE PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190322625-A1 | MONO-(ACID) SALTS OF 6-AMINOISOQUINOLINES AND USES THEREOF | AADAT, SLC10A1, SLC10A2 | ROCK2 3307/4885ROCK1 3706/4885 |
| US-11028081-B2 | Dual mechanism inhibitors for the treatment of disease | RHOA, SLC6A2, ROCK2 | ROCK2 3/4885ROCK1 10/4885 |
| US-20220144778-A1 | MONO-(ACID) SALTS OF 6-AMINOISOQUINOLINES AND USES THEREOF | AADAT, SLC10A1, SLC10A2 | ROCK2 3307/4885ROCK1 3706/4885 |
| US-20210363141-A1 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | RHOA, SLC6A2, ROCK2 | ROCK2 3/4885ROCK1 10/4885 |
| US-20100280011-A1 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | RHOA, SLC6A2, ROCK2 | ROCK2 3/4885ROCK1 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.