Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11401796 | 0.89 | ALDH1A1 (0.52) | ADRB2HTR6GSK3BALDH1A1KDM4E | |
| SCHEMBL11388955 | 0.81 | MAPT (0.40) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL11390014 | 0.80 | ALDH1A1 (0.50) | GSK3BALDH1A1RAB9AKDM4EMEN1 | |
| SCHEMBL11389627 | 0.80 | TP53 (0.39) | GSK3BALDH1A1KDM4EMEN1POLB | |
| SCHEMBL11390048 | 0.80 | KMT2A (0.48) | GSK3BRAB9AKDM4EMEN1POLB | |
| SCHEMBL11395443 | 0.77 | ALDH1A1 (0.37) | ALDH1A1RAB9AKDM4EHPGDMEN1 | |
| SCHEMBL6050620 | 0.76 | ALDH1A1 (0.45) | GSK3BALDH1A1RAB9AKDM4EPOLB | |
| SCHEMBL11398592 | 0.76 | GSK3B (0.41) | GSK3BALDH1A1RAB9AKDM4EHPGD | |
| SCHEMBL11399663 | 0.76 | TP53 (0.34) | GSK3BKDM4EPOLB | |
| SCHEMBL11402630 | 0.76 | GSK3B (0.37) | GSK3BALDH1A1RAB9AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4302460-A | 4-Quinolinones having antihypertensive activity | THE BOOTS COMPANY LIMITED (GB) | 1981-11-24 | — | — | US | disclosed |