Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11389627 | 0.89 | TP53 (0.39) | TP53SMN1; SMN2KDM4EGSK3BPOLB | |
| SCHEMBL11398592 | 0.84 | GSK3B (0.41) | TP53SMN1; SMN2KDM4EGSK3BCDK1 | |
| SCHEMBL11402630 | 0.82 | GSK3B (0.37) | TP53SMN1; SMN2KDM4EGSK3BCDK1 | |
| SCHEMBL11401167 | 0.76 | TP53 (0.34) | TP53SMN1; SMN2POLBL3MBTL1THRB | |
| SCHEMBL11391212 | 0.76 | TP53 (0.36) | TP53NCOA1NCOA3SMN1; SMN2GSK3B | |
| SCHEMBL11399722 | 0.76 | ADRB2 (0.47) | KDM4EGSK3BPOLB | |
| SCHEMBL11401796 | 0.76 | ALDH1A1 (0.52) | KDM4EGSK3BL3MBTL1 | |
| SCHEMBL11390014 | 0.75 | ALDH1A1 (0.50) | KDM4EGSK3BCDK1CCNB1CDK2 | |
| Flosequinan SCHEMBL122877 | 0.75 | ATM (0.47) | TP53KDM4EGSK3BCDK4CCND1 | |
| Flosequinan SCHEMBL5441172 | 0.75 | ATM (0.47) | TP53KDM4EGSK3BCDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4302460-A | 4-Quinolinones having antihypertensive activity | THE BOOTS COMPANY LIMITED (GB) | 1981-11-24 | — | — | US | disclosed |