Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6050631 | 0.88 | THRB (0.46) | THRBLMNANTRK1RXFP1POLB | |
| SCHEMBL10631654 | 0.87 | THRB (0.45) | THRBLMNANTRK1RXFP1POLB | |
| SCHEMBL6050595 | 0.84 | THRB (0.43) | THRBLMNANTRK1RXFP1POLB | |
| SCHEMBL10629380 | 0.84 | THRB (0.43) | THRBLMNANTRK1RXFP1POLB | |
| SCHEMBL6050597 | 0.82 | ATM (0.48) | THRBLMNARXFP1POLBTP53 | |
| SCHEMBL7318523 | 0.81 | NTRK1 (0.41) | THRBLMNANTRK1HTR6KMT2A | |
| SCHEMBL11391444 | 0.81 | TP53 (0.40) | THRBLMNAPOLBTP53L3MBTL1 | |
| SCHEMBL22450691 | 0.80 | KMT2A (0.43) | THRBLMNARXFP1POLBGAA | |
| SCHEMBL22824067 | 0.80 | TRPV4 (0.44) | THRBLMNANTRK1RXFP1POLB | |
| SCHEMBL11389667 | 0.79 | ALDH1A1 (0.54) | NTRK1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4302460-A | 4-Quinolinones having antihypertensive activity | THE BOOTS COMPANY LIMITED (GB) | 1981-11-24 | — | — | US | disclosed |