Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.44 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | SCN4A | P35499 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25408858 | 0.82 | KEAP1 (0.47) | HRH3BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL11246577 | 0.80 | BMPR1B (0.46) | CA1CA2HRH3BMPR1BBMPR1A | |
| SCHEMBL6538527 | 0.79 | PDE10A (0.40) | HRH3HDAC6BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL11391433 | 0.78 | HRH3 (0.52) | CA1CA2HRH3KDM4EALDH1A1 | |
| SCHEMBL5147968 | 0.78 | ADORA2A (0.65) | HRH3HDAC6BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL6538398 | 0.78 | ADORA2A (0.50) | CA1CA2HRH3HDAC6BMPR1B | |
| SCHEMBL6539242 | 0.78 | HTR2A (0.39) | CA1CA2HRH3HDAC6BMPR1B | |
| SCHEMBL6134033 | 0.77 | TGFBR1 (0.48) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL5148995 | 0.77 | ADORA2A (0.49) | HRH3HDAC6BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL5148931 | 0.76 | ADORA2A (0.46) | HDAC6ADORA2AADORA1HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4289774-A | Lipid lowering and anti-thrombotic 6-arylpyridazin-3-ones and a process for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-09-15 | — | — | US | disclosed |
| EP-0010156-A1 | 6-Arylpyridazine-3-ones, pharmaceutical compositions containing them and process for their preparation | MERCK PATENT GmbH (DE) | 1980-04-30 | — | — | EP | disclosed |