Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11392783 | 0.83 | KDM4E (0.36) | GSK3BCDK2CYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL11392937 | 0.83 | PCSK9 (0.36) | BRD4ALDH1A1KDM4EHPGD | |
| SCHEMBL11398654 | 0.81 | ALDH1A1 (0.49) | MAPTGAAATMALDH1A1LMNA | |
| SCHEMBL6050620 | 0.78 | ALDH1A1 (0.45) | GSK3BMAPTCDK2ALDH1A1LMNA | |
| SCHEMBL11401167 | 0.73 | TP53 (0.34) | MAPTATMALDH1A1 | |
| SCHEMBL11087730 | 0.72 | ALKBH5 (0.48) | BRD4ALKBH5FTOGSK3BMAPT | |
| SCHEMBL11388955 | 0.71 | MAPT (0.40) | MAPTGAAATMALDH1A1LMNA | |
| SCHEMBL7317623 | 0.71 | TP53 (0.38) | GSK3BMAPTCDK2ALDH1A1KMT2A | |
| SCHEMBL10746141 | 0.69 | — | — | |
| SCHEMBL11406847 | 0.69 | TP53 (0.35) | MAPTGAAATMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4302460-A | 4-Quinolinones having antihypertensive activity | THE BOOTS COMPANY LIMITED (GB) | 1981-11-24 | — | — | US | disclosed |