Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11388955 | 0.88 | MAPT (0.40) | TP53MAPTALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL10943341 | 0.84 | NTRK1 (0.40) | TP53GSK3BMAPTTHRBCDK2 | |
| SCHEMBL7316129 | 0.84 | GSK3B (0.35) | GSK3BALDH1A1CDK2 | |
| Flosequinan SCHEMBL5441172 | 0.84 | ATM (0.47) | TP53PRKCAGSK3BMAPTALDH1A1 | |
| Flosequinan SCHEMBL122877 | 0.84 | ATM (0.47) | TP53PRKCAGSK3BMAPTALDH1A1 | |
| Flosequinan SCHEMBL5442796 | 0.84 | ATM (0.47) | TP53PRKCAGSK3BMAPTALDH1A1 | |
| Flosequinan SCHEMBL6535622 | 0.82 | ATM (0.46) | TP53PRKCAGSK3BMAPTALDH1A1 | |
| SCHEMBL11406579 | 0.82 | HTR1D (0.39) | ALDH1A1 | |
| SCHEMBL11401644 | 0.82 | KDM4E (0.31) | MAPTALDH1A1KDM4E | |
| SCHEMBL11401697 | 0.82 | MAPT (0.32) | TP53PRKCAGSK3BMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4552884-A | Method of treating heart disease | THE BOOTS COMPANY PLC (GB) | 1985-11-12 | — | — | US | disclosed |
| EP-0149519-A2 | Use of quinolones for the manufacture of a composition for the treatment of heart failure. | The Boots Company PLC (GB) | 1985-07-24 | — | — | EP | disclosed |
| US-4302460-A | 4-Quinolinones having antihypertensive activity | THE BOOTS COMPANY LIMITED (GB) | 1981-11-24 | — | — | US | disclosed |