Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methimazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPO | P22079 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methimazole SCHEMBL41647 | 0.89 | — | — | |
| Methimazole SCHEMBL1816808 | 0.89 | LPO (0.50) | LPOFDPSKMT2AMEN1HTT | |
| Methimazole SCHEMBL6189739 | 0.86 | — | — | |
| Methimazole SCHEMBL28774524 | 0.86 | — | — | |
| Methimazole SCHEMBL2267872 | 0.86 | — | — | |
| Methimazole SCHEMBL11566410 | 0.86 | — | — | |
| Methimazole SCHEMBL17287217 | 0.86 | — | — | |
| Methimazole SCHEMBL28849331 | 0.78 | LPO (0.41) | LPOFDPSKMT2AMEN1HTT | |
| Methimazole SCHEMBL25206387 | 0.75 | LPO (0.39) | LPO | |
| SCHEMBL10714479 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4230796-A | High speed lithographic film element | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-10-28 | — | — | US | disclosed |